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Table 1 Current amplitudes and Mg2+ block of coexpressed mutant NMDAR subunits

From: Residues at the tip of the pore loop of NR3B-containing NMDA receptors determine Ca2+ permeability and Mg2+block

  IGly[nA] ± SEM (n) IGlu/Gly[nA] ± SEM (n) Mg2+Block IGly[%] ± SEM (n) Mg2+Block IGlu/Gly[%] ± SEM (n)
NR1-3a/NR2B 164 ± 38 (33) 2122 ± 328 (48) 125 ± 10 (20) 88 ± 3 (24)
NR1-3a/NR2B(GN) 827 ± 195 (11) 6959 ± 808.0 (11) 97 ± 25 (5) 71 ± 8 (7)
NR1-3a(GS)/NR2B 216 ± 43 (11) 5080 ± 1448 (12) 82 ± 12 (9) 56 ± 6 (8)
NR1-3a(GS)/NR2B(GN) 1764 ± 348 (11) 13076 ± 803 (11) 57 ± 5 (8) 25 ± 9 (8)
NR1-3a/NR3B 149 ± 27 (45) 171 ± 30 (45) 3 ± 1 (27) 13 ± 4 (15)
NR1-3a/NR3B(NR) 213 ± 62 (15) 258 ± 93 (15) 34 ± 8 (11) 30 ± 4 (11)
NR1-3a/NR3B(GN) 294 ± 42 (5) 476 ± 63 (5) 38 ± 6 (5) 46 ± 4 (5)
NR1-3a/NR3B(NS) 116 ± 68 (18) 170 ± 98 (18) 8 ± 8 (12) 31 ± 14 (15)
NR1-3a(GS)/NR3B 176 ± 64 (13) 200 ± 70 (13) -3 ± 6 (9) -4 ± 10 (10)
NR1-3a(GS)/NR3B(NR) 251 ± 79 (5) 361 ± 78 (5) -3 ± 2 (5) 6 ± 3 (5)
NR1-3a(GS)/NR3B(GN) 579 ± 196 (5) 698 ± 194 (6) 5 ± 4 (5) 7 ± 3 (6)
NR1-3a(GS)/NR3B(NS) 252 ± 79 (5) 361 ± 78 (5) -3 ± 2 (5) 6 ± 3 (5)
  1. Overview of all current amplitudes and Mg2+ blocks as shown in Figs. 1 and 4. Current responses are mediated by diheteromers featuring N and N+1 site mutant NMDAR subunits measured upon activation by either glycine alone (Gly, 10 μM) or by Gly in addition to glutamate (Glu, 100 μM). Values for current responses are given in nA ± SEM (standard error of the mean). The Mg2+ block is given as % of blocked steady-state current ± SEM. n = number of cells.
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