Figure 4From: Role of ionotropic GABA, glutamate and glycine receptors in the tonic and reflex control of cardiac vagal outflow in the ratRole of GABAergic and glycinergic neurotransmission in regions of the medulla containing cardiac vagal preganglionic neurons in cardio-vagal responses to 5-HT 1A receptor activation. Panel A illustrates the effects of intravenous injection of the 5-HT1A agonist 8-OH-DPAT (0.1 mg/kg, n = 9) on heart rate (HR) and baroreflex bradycardia. Panels B and C shows the intravenous injection of 8-OH-DPAT on HR and baroreflex bradycardia following prior microinjection of the GABAA antagonist picrotoxin (2 mM, n = 6) and glycine antagonist strychnine (3 mM, n = 4) into regions of the medulla containing cardiac vagal preganglionic neurons respectively. Panel D shows that an injection of 8-OH-DPAT alone evokes a small bradycardia which is not altered by prior microinjection of picrotoxin. Prior microinjection of strychnine prevents this bradycardia. Panel E shows that injections of 8-OH-DPAT alone increase baroreflex sensitivity (BRS). This increase in BRS is still seen following prior microinjection of picrotoxin but not strychnine. * P < 0.05, ** P < 0.01.Back to article page