Figure 5

Dose-response curves of XapEn. Dependence of cross-approximate entropy on anesthetic concentration expressed in MAC. The data points represent values from all non-redundant pairwise combinations of recording sites, normalized to control and averaged (± standard deviation). Single detached data points at negative abscissa values represent values after recovery (open symbols; no recovery data were recorded for rat 3). The solid lines are fits of the data to the monexponential function y = exp(-x/tau) with tau as the only free parameter. Coefficient of determination (R²) values ranged from 0.85 to 0.91, indicating that the fits were adequate. Dotted lines represent upper and lower 95% prediction bounds of the fits. The blue rectangles in the background depict a range of published MAC_awake values (see main text).