Figure 1

Study design comprising a comprehensive cross-sectional baseline evaluation and 2 longitudinal phases with high-frequency followed by low-frequency testing. With a semi-structured interview, sociodemographic variables and medical history were collected. Drug screening: Urine samples of all subjects were tested for ethanol, cannabinoids, benzodiazepines and cocaine at baseline, and tests were repeated randomly afterwards. MWT-B, Mehrfachwahl-Wortschatz-Intelligenz-Test (premorbid intelligence measure); HAWIE-R, revised German version of the Wechsler Adult Intelligence Scale (subtests Information, Similarities, Picture Completion, Block Design); NEO-PI-R, revised NEO Personality Inventory; QoL, quality of life visual-analogue scale; PANSS, Positive and Negative Syndrome Scale; HAMD, Hamilton Rating Scale for Depression; MacQuarrie; MacQuarrie Tapping and Dotting tests; Purdue Pegboard, Purdue Pegboard Test, TAP, Test for Attentional Performance (subtests Alertness, Visual Scanning, Working Memory, Flexibility); TMT, Trail Making Test (A and B); WMS-III, Wechsler Memory Scale - 3^rd edition (subtest Letter Number Sequencing); RWT, Regensburger Wortflüssigkeitstest (subtest phonemic verbal fluency); RBANS, Repeatable Battery for the Assessment of Neuropsychological Status (Full Scale, complete RBANS performed; Attention, RBANS Attention subtests only); WCST-64, Wisconsin Card Sorting Test - 64 Card Version.