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Figure 2 | BMC Neuroscience

Figure 2

From: Impaired adult olfactory bulb neurogenesis in the R6/2 mouse model of Huntington's disease

Figure 2

R6/2 mice show increased migration of neuroblasts to the affected striatum compared to controls, without signs of substantial striatal neurogenesis. Representative images of DCX-expressing neuroblasts in wild-type (WT; A) and R6/2 mice (R6/2; B), higher magnification (from insert in B) of cells exhibiting heterogeneous morphologies (C): Some cells possess only short or no processes, some display multiple well-developed processes characteristic of migrating cells. Arrows indicate migrating DCX positive cells leaving the SVZ. Quantification of DCX-positive cells in the striatum of WT and R6/2 mice, predominantly in close proximity to the SVZ (D). Error bars represent SD, * indicates p < 0.05. Scale bars represent 50 μm.

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