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Figure 2 | BMC Neuroscience

Figure 2

From: Upregulation of synaptotagmin IV inhibits transmitter release in PC12 cells with targeted synaptotagmin I knockdown

Figure 2

Syt IV expression in syt I knockdown cells reduced evoked secretion. Representative amperometry recordings are shown from an untreated control cell (A), forskolin-treated control cell (B), untreated shRNA-syt I knockdown cell (C), and a forskolin-treated shRNA-syt I knockdown cell (D). The arrows depict where the continuously perfused solution was changed from HBSS to 50 mM K+ stimulating solution. (E) The average number of events per cell group is shown in the plot for forskolin-treated control (n = 19), shRNA-syt I knockdown (n = 16), and control transfected, CT (n = 12) cells, compared to untreated control (n = 24), shRNA-syt I knockdown (n = 24) and CT (n = 15) cells (**p < 0.01).

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