|  |  |  | c-Fos counts in a 325 × 425 μm area | ||||
---|---|---|---|---|---|---|---|---|
 | Region |  |  | PIC-SUM (N = 14) | PIC-OUT (N = 7) | VEH (N = 9) | ||
 |  | Distance (mm) | Hemi-sphere | Mean | P-value | Mean | P-value | Mean |
Cortex | Medial prefrontal cortex | 2.8 | i | 71.4 | 0.0042 | 40.7 | 0.2695 | 26.3 |
 |  | 2.8 | c | 60.2 | 0.0399 | 30.6 | 0.8129 | 27.7 |
 | Retrosplenial granular cortex | -2.8 | i | 50.2 | 0.0572 | 45.4 | 0.0402 | 5.7 |
 |  | -2.8 | c | 35.8 |  | 32.7 |  | 8.4 |
 | Hippocampus dentate gyrus | -2.8 | i | 44.1 |  | 14.4 |  | 1.6 |
 |  | -2.8 | c | 41.3 |  | 7.9 |  | 1.9 |
 | Basolateral nucleus of amygdala | -2.8 | i | 11.8 |  | 18.3 |  | 3.3 |
 |  | -2.8 | c | 12.9 |  | 17.3 |  | 4.6 |
Basal forebrain | Central nucleus of amygdala | -2.8 | i | 6.6 | Â | 33.1 | Â | 8.2 |
 |  | -2.8 | c | 6.9 |  | 7.0 |  | 6.2 |
 | Lateral septal nucleus, dorsal part | 2.0 | i | 43.7 | 0.0565 | 56.3 | 0.0263 | 11.4 |
 |  | 2.0 | c | 38.7 |  | 41.1 |  | 12.2 |
 |  | 1.0 | i | 13.0 |  | 24.1 |  | 1.6 |
 |  | 1.0 | c | 10.3 |  | 22.3 |  | 1.6 |
 |  | 0.0 | i | 18.4 | 0.0261 | 6.4 | 0.4434 | 1.8 |
 |  | 0.0 | c | 17.4 | 0.0369 | 10.6 | 0.1427 | 1.3 |
 | Lateral septal nucleus, intermediate part | 2.0 | i | 72.9 | 0.0009 | 16.6 | 0.5070 | 5.8 |
 |  | 2.0 | c | 43.9 | 0.0016 | 13.4 | 0.5993 | 8.7 |
 |  | 1.0 | i | 194.1 | 0.0004 | 74.4 | 0.1148 | 7.7 |
 |  | 1.0 | c | 99.9 | 0.0045 | 35.4 | 0.3642 | 12.4 |
 |  | 0.0 | i | 57.1 | 0.0084 | 26.1 | 0.1900 | 4.3 |
 |  | 0.0 | c | 45.3 | 0.0086 | 17.0 | 0.3078 | 3.7 |
 | Lateral septal nucleus, ventral part | 2.0 | i | 150.1 | 0.0009 | 76.9 | 0.0730 | 18.0 |
 |  | 2.0 | c | 86.3 | 0.0084 | 57.0 | 0.0887 | 22.2 |
 |  | 1.0 | i | 297.4 | 0.0002 | 102.9 | 0.1898 | 32.3 |
 |  | 1.0 | c | 158.1 | 0.0017 | 52.6 | 0.6105 | 36.6 |
 |  | 0.0 | i | 139.6 | 0.0031 | 96.9 | 0.0205 | 8.6 |
 |  | 0.0 | c | 81.1 | 0.0065 | 61.4 | 0.0202 | 6.9 |
 | Septohypothalamic nucleus | 0.0 | i | 127.1 | 0.0009 | 55.6 | 0.1279 | 12.0 |
 |  | 0.0 | c | 73.0 | 0.0144 | 54.9 | 0.0423 | 11.7 |
 | Medial septal nucleus | 1.0 | i | 17.2 |  | 10.4 |  | 6.4 |
 |  | 0.0 | c | 18.9 | 0.0136 | 14.7 | 0.0290 | 1.7 |
 | Nucleus of the vertical limb of the diagonal band | 1.0 | i | 21.9 | 0.0356 | 10.0 | 0.2844 | 1.6 |
 |  | 1.0 | c | 6.2 |  | 10.1 |  | 1.1 |
 | Nucleus of the horizontal limb of the diagonal band | 1.0 | i | 19.0 | 0.0097 | 11.6 | 0.0778 | 1.6 |
 |  | 1.0 | c | 4.3 |  | 6.1 |  | 1.7 |
 | Nucleus accumbens core | 2.0 | i | 31.4 |  | 4.6 |  | 2.9 |
 |  | 2.0 | c | 25.9 | 0.0434 | 2.0 | 0.8836 | 3.6 |
 |  | 1.0 | i | 12.6 |  | 3.4 |  | 2.1 |
 |  | 1.0 | c | 9.6 |  | 3.4 |  | 2.8 |
 | Nucleus accumbens shell, medial part | 2.0 | i | 48.2 | 0.0012 | 7.1 | 0.8499 | 5.1 |
 |  | 2.0 | c | 43.8 | 0.0022 | 10.6 | 0.6573 | 6.1 |
 |  | 1.0 | i | 23.4 | 0.0202 | 12.9 | 0.1577 | 2.4 |
 |  | 1.0 | c | 18.6 | 0.0361 | 8.4 | 0.3962 | 3.4 |
 | Olfactory tubercle | 2.0 | i | 7.4 |  | 5.9 |  | 1.3 |
 |  | 2.0 | c | 6.4 |  | 12.0 |  | 1.9 |
Thalamus | Paraventricular thalamic nucleus | -1.0 | i | 50.2 | Â | 29.4 | Â | 39.2 |
 |  | -1.0 | c | 41.4 |  | 29.9 |  | 36.0 |
 |  | -2.0 | m | 72.1 |  | 79.4 |  | 76.1 |
 | Central medial thalamic n | -2.0 | m | 43.6 |  | 45.4 |  | 31.1 |
 | Lateral habenula | -3.0 | i | 18.7 |  | 18.9 |  | 18.2 |
 |  | -3.0 | c | 47.1 | 0.0494 | 24.0 | 0.4813 | 14.7 |
Hypothalamus | Medial preoptic area | 0.0 | i | 34.1 | Â | 15.7 | Â | 9.8 |
 |  | 0.0 | c | 18.6 |  | 12.1 |  | 11.3 |
 | Lateral preoptic area | 0.0 | i | 45.5 | 0.0313 | 50.3 | 0.0422 | 7.3 |
 |  | 0.0 | c | 30.0 |  | 37.6 |  | 8.1 |
 |  | -1.0 | i | 35.3 | 0.0118 | 39.9 | 0.0120 | 2.2 |
 |  | -1.0 | c | 19.7 | 0.0083 | 35.9 | 0.0001 | 2.4 |
 | Dorsomedial hypothalamic nucleus | -3.0 | i | 47.7 | 0.0042 | 6.9 | 0.6072 | 12.7 |
 |  | -3.0 | c | 36.6 | 0.0826 | 7.4 | 0.4753 | 15.8 |
 | Lateral hypothalamic area | -2.0 | i | 30.1 | 0.0120 | 22.0 | 0.0444 | 4.9 |
 |  | -2.0 | c | 20.0 | 0.0166 | 23.1 | 0.0131 | 4.3 |
 | Supramammillary n | -4.0 | m | 187.0 | 0.0021 | 141.0 | 0.0170 | 48.3 |
Midbrain | Anterolateral VTA | -5.0 | i | 23.1 | 0.0603 | 4.9 | 0.7089 | 1.4 |
 |  | -5.0 | c | 1.8 |  | 1.9 |  | 1.6 |
 | Posterior VTA | -5.8 | i | 9.6 | 0.0135 | 4.1 | 0.2728 | 1.0 |
 |  | -5.8 | c | 3.7 |  | 3.6 |  | 1.0 |
 | Central linear n | -6.7 | m | 3.9 |  | 3.6 |  | 1.0 |
 | Dorsal raphe n | -7.8 | m | 21.1 | 0.0251 | 16.0 | 0.0498 | 1.7 |
 | Median raphe n | -7.8 | m | 15.4 |  | 20.1 |  | 1.3 |