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Table 1 c-Fos counts in reward-related regions following an injection of either vehicle or picrotoxin into the SuM or its vicinity

From: Administration of the GABAA receptor antagonist picrotoxin into rat supramammillary nucleus induces c-Fos in reward-related brain structures. Supramammillary picrotoxin and c-Fos expression

     c-Fos counts in a 325 × 425 μm area
  Region    PIC-SUM (N = 14) PIC-OUT (N = 7) VEH (N = 9)
   Distance (mm) Hemi-sphere Mean P-value Mean P-value Mean
Cortex Medial prefrontal cortex 2.8 i 71.4 0.0042 40.7 0.2695 26.3
   2.8 c 60.2 0.0399 30.6 0.8129 27.7
  Retrosplenial granular cortex -2.8 i 50.2 0.0572 45.4 0.0402 5.7
   -2.8 c 35.8   32.7   8.4
  Hippocampus dentate gyrus -2.8 i 44.1   14.4   1.6
   -2.8 c 41.3   7.9   1.9
  Basolateral nucleus of amygdala -2.8 i 11.8   18.3   3.3
   -2.8 c 12.9   17.3   4.6
Basal forebrain Central nucleus of amygdala -2.8 i 6.6   33.1   8.2
   -2.8 c 6.9   7.0   6.2
  Lateral septal nucleus, dorsal part 2.0 i 43.7 0.0565 56.3 0.0263 11.4
   2.0 c 38.7   41.1   12.2
   1.0 i 13.0   24.1   1.6
   1.0 c 10.3   22.3   1.6
   0.0 i 18.4 0.0261 6.4 0.4434 1.8
   0.0 c 17.4 0.0369 10.6 0.1427 1.3
  Lateral septal nucleus, intermediate part 2.0 i 72.9 0.0009 16.6 0.5070 5.8
   2.0 c 43.9 0.0016 13.4 0.5993 8.7
   1.0 i 194.1 0.0004 74.4 0.1148 7.7
   1.0 c 99.9 0.0045 35.4 0.3642 12.4
   0.0 i 57.1 0.0084 26.1 0.1900 4.3
   0.0 c 45.3 0.0086 17.0 0.3078 3.7
  Lateral septal nucleus, ventral part 2.0 i 150.1 0.0009 76.9 0.0730 18.0
   2.0 c 86.3 0.0084 57.0 0.0887 22.2
   1.0 i 297.4 0.0002 102.9 0.1898 32.3
   1.0 c 158.1 0.0017 52.6 0.6105 36.6
   0.0 i 139.6 0.0031 96.9 0.0205 8.6
   0.0 c 81.1 0.0065 61.4 0.0202 6.9
  Septohypothalamic nucleus 0.0 i 127.1 0.0009 55.6 0.1279 12.0
   0.0 c 73.0 0.0144 54.9 0.0423 11.7
  Medial septal nucleus 1.0 i 17.2   10.4   6.4
   0.0 c 18.9 0.0136 14.7 0.0290 1.7
  Nucleus of the vertical limb of the diagonal band 1.0 i 21.9 0.0356 10.0 0.2844 1.6
   1.0 c 6.2   10.1   1.1
  Nucleus of the horizontal limb of the diagonal band 1.0 i 19.0 0.0097 11.6 0.0778 1.6
   1.0 c 4.3   6.1   1.7
  Nucleus accumbens core 2.0 i 31.4   4.6   2.9
   2.0 c 25.9 0.0434 2.0 0.8836 3.6
   1.0 i 12.6   3.4   2.1
   1.0 c 9.6   3.4   2.8
  Nucleus accumbens shell, medial part 2.0 i 48.2 0.0012 7.1 0.8499 5.1
   2.0 c 43.8 0.0022 10.6 0.6573 6.1
   1.0 i 23.4 0.0202 12.9 0.1577 2.4
   1.0 c 18.6 0.0361 8.4 0.3962 3.4
  Olfactory tubercle 2.0 i 7.4   5.9   1.3
   2.0 c 6.4   12.0   1.9
Thalamus Paraventricular thalamic nucleus -1.0 i 50.2   29.4   39.2
   -1.0 c 41.4   29.9   36.0
   -2.0 m 72.1   79.4   76.1
  Central medial thalamic n -2.0 m 43.6   45.4   31.1
  Lateral habenula -3.0 i 18.7   18.9   18.2
   -3.0 c 47.1 0.0494 24.0 0.4813 14.7
Hypothalamus Medial preoptic area 0.0 i 34.1   15.7   9.8
   0.0 c 18.6   12.1   11.3
  Lateral preoptic area 0.0 i 45.5 0.0313 50.3 0.0422 7.3
   0.0 c 30.0   37.6   8.1
   -1.0 i 35.3 0.0118 39.9 0.0120 2.2
   -1.0 c 19.7 0.0083 35.9 0.0001 2.4
  Dorsomedial hypothalamic nucleus -3.0 i 47.7 0.0042 6.9 0.6072 12.7
   -3.0 c 36.6 0.0826 7.4 0.4753 15.8
  Lateral hypothalamic area -2.0 i 30.1 0.0120 22.0 0.0444 4.9
   -2.0 c 20.0 0.0166 23.1 0.0131 4.3
  Supramammillary n -4.0 m 187.0 0.0021 141.0 0.0170 48.3
Midbrain Anterolateral VTA -5.0 i 23.1 0.0603 4.9 0.7089 1.4
   -5.0 c 1.8   1.9   1.6
  Posterior VTA -5.8 i 9.6 0.0135 4.1 0.2728 1.0
   -5.8 c 3.7   3.6   1.0
  Central linear n -6.7 m 3.9   3.6   1.0
  Dorsal raphe n -7.8 m 21.1 0.0251 16.0 0.0498 1.7
  Median raphe n -7.8 m 15.4   20.1   1.3
  1. Notes: c-Fos counts in bold indicate significant differences from respective counts for vehicle injections. Blank space in the p-value columns indicates that the effect of region was not significant, following an ANOVA/MANOVA test. Abbreviations: c, contralateral to injection site; i, ipsilateral to injection site; m, midline; n, nucleus