Figure 1

Assessment of neurological and behavioural deficits. (A) Neurological scoring (B) Percentage of lactacystin-lesioned animals that are impaired in each of the neurological score tests at days 3, 7 and 21. (C) No significant reduction in forelimb grip strength was observed in saline-injected controls. By contrast in lactacystin-lesioned animals (D) forelimb grip strength was significantly reduced in the contralateral forelimb at 1 and 3 weeks post-lesion. Data shown are mean forelimb grip force (g) ± SEM *p < 0.01 saline vs. lactacystin. (C) Lactacystin-lesioned animals displayed significantly increased rotational asymmetry in response to apomorphine challenge (0.1 mg/kg s.c.), Data shown are mean area under curve (AUC) ± SEM ***p < 0.001 saline vs. lactacystin.