Figure 3
From: Presynaptic action of neurotensin on dopamine release through inhibition of D2 receptor function
Neurotensin facilitates train pulse- but not single pulse-evoked DA overflow in the NAcc. A) Graphs representing the average amplitude and kinetics of single-pulse (lower traces) and train-pulse (upper traces) evoked DA overflow in the presence of NT (8–13) (100 nM) compared to control. B) Time course of peak DA overflow evoked by single electrical pulses. NT (8–13) (100 nM) was applied for a total of 8 min. It exerted no effect on single pulse-evoked DA overflow (n = 5). C) Time course of peak DA overflow evoked by train pulses. NT (8–13) strongly enhanced train-evoked DA overflow (n = 13). Data are expressed as a percentage of the DA levels recorded during the control period before NT.