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Figure 1 | BMC Neuroscience

Figure 1

From: Paraquat induces oxidative stress, neuronal loss in substantia nigra region and Parkinsonism in adult rats: Neuroprotection and amelioration of symptoms by water-soluble formulation of Coenzyme Q10

Figure 1

Schematic outlines of experimental procedures. A) Experiment 1: Four experimental groups of animals were provided with indicated water or water supplemented with placebo or WS-CoQ10. Three weeks later, they received intraperitoneal injections (open circles) of saline or PQ (10 mg/kg) once a week for 3 consecutive weeks. One week following the last injection (dark arrow), rats were sacrificed and brain tissue was collected for immunohistochemical studies. B) Experiment 2: Four experimental groups of animals were given either placebo or WS-CoQ10 supplemented drinking water (as indicated). Three weeks later, they received intraperitoneal injections (open circles) of saline or PQ (10 mg/kg) once a week for 3 consecutive weeks. Rats were trained on the rotorod during the pre-injection period (grey arrowheads) and behavioural assessment was conducted on the third, fourth and fifth rotorod sessions (dark arrowhead). Two weeks following the last injections, rats were sacrificed and brain tissue was collected for biochemical studies (dark arrow).

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