Neuroprotective efficacy of 5HT1A agonist DU123015 and positive control MK-801 in the 90 minutes Intra-Luminal Tread (ILT) model of MCAo. The body weights of animals treated with DU123015 (A) and MK-801 (B). (C) No significant differences were observed on neurological functions in animals treated with DU123015 (D) A Kruskall-Wallis non-parametric test indicated that MK-801 improved neurological functions impaired by stroke. (E) No significant differences were observed on oedema corrected MRI lesion volume for DU123015-treated animals. (F) In contrast, MK-801 significantly reduced lesion volume at all time points (*) P < 0.05 (**) P < 0.01.