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Figure 3 | BMC Neuroscience

Figure 3

From: Src kinase up-regulates the ERK cascade through inactivation of protein phosphatase 2A following cerebral ischemia

Figure 3

Effects of SU on the Src/PP2A C signaling pathways in response to cerebral ischemia. SU or its Veh was administered into the left intracerebral ventricle 20 min prior to occlusion. 24 h post-ischemic reperfusion was performed. Proteins were measured using the same antibodies mentioned in Figure 2. (A) Determination of p-Src levels with and without SU during 24 h reperfusion following 10 min ischemia. (B) Determination of p-PP2A C levels with and without SU following cerebral ischemia. (C) Alteration of PP2A C activity following post-ischemic reperfusion. (D) β-actin with and without SU during reperfusion post-ischemia. O.D. is presented as fold-increase compared to sham control levels. Data are expressed as mean ± S.D. (n = 4/group), *P < 0.05 vs. sham control.

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