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Table 1 Average levels ± SEM of measured absolute metabolites in institutional units for NAA, Glx, Cr, Cho and MI in SIV infected macaques analyzed by in vivo MR spectroscopy

From: In vivo proton magnetic resonance spectroscopy reveals region specific metabolic responses to SIV infection in the macaque brain

   Frontal Cortex White Matter Basal Ganglia
NAA Uninfected 6.86 ± 0.19 7.94 ± 0.24 7.38 ± 0.15
  2 wpi 6.26 ± 0.15 7.82 ± 0.13 7.17 ± 0.16
  4 wpi 6.83 ± 0.79 7.92 ± 0.65 7.22 ± 0.68
  RM ANOVA P = 0.025 NS NS
  Holm't t-test pre – 2 wpi. P = 0.011   
  Holm's t-test pre – 4 wpi NS   
  Holm's t-test 2 wpi – 4 wpi P = 0.035   
  Paired t-test pre – 2 wpi P = 0.021 NS NS
Glx Uninfected 12.30 ± 0.26 11.71 ± 0.32 11.96 ± 0.23
  2 wpi 11.81 ± 0.29 11.14 ± 0.38 11.07 ± 0.29
  4 wpi 12.80 ± 0.29 11.26 ± 0.31 12.03 ± 0.30
  RM ANOVA NS NS NS
  Holm't t-test pre – 2 wpi    
  Holm's t-test pre – 4 wpi    
  Holm's t-test 2 wpi – 4 wpi    
  Paired t-test pre – 2 wpi NS NS P = 0.052
Cr Uninfected 5.60 ± 0.09 5.76 ± 0.14 6.65 ± 0.10
  2 wpi 5.450 ± 0.13 6.15 ± 0.13 6.49 ± 0.08
  4 wpi 5.78 ± 0.10 6.01 ± 0.18 6.53 ± 0.14
  RM ANOVA NS P = 0.025 NS
  Holm't t-test pre – 2 wpi   P = 0.007  
  Holm's t-test pre – 4 wpi   NS  
  Holm's t-test 2 wpi – 4 wpi   NS  
  Paired t-test pre – 2 wpi NS P = 0.003 NS
Cho Uninfected 1.014 ± 0.03 0.9754 ± 0.04 1.18 ± 0.03
  2 wpi 1.066 ± 0.025 1.078 ± 0.05 1.20 ± 0.04
  4 wpi 0.91 ± 0.04 0.9334 ± 0.04 1.10 ± 0.06
  RM ANOVA P < 0.0001 P = 0.007 NS
  Holm't t-test pre – 2 wpi P = 0.077 P = 0.008  
  Holm's t-test pre – 4 wpi P = 0.016 NS  
  Holm's t-test 2 wpi – 4 wpi P < 0.0001 P = 0.004  
  Paired t-test pre – 2 wpi NS NS NS
MI Uninfected 5.25 ± 0.14 4.72 ± 0.18 5.06 ± 0.12
  2 wpi 5.81 ± 0.08 5.15 ± 0.13 5.21 ± 0.15
  4 wpi 5.98 ± 0.23 5.45 ± 0.23 5.45 ± 0.18
  RM ANOVA P = 0.048 P = 0.033 NS
  Holm't t-test pre – 2 wpi P = 0.080 P = 0.051  
  Holm's t-test pre – 4 wpi P = 0.018 P = 0.013  
  Holm's t-test 2 wpi – 4 wpi NS NS  
  Paired t-test pre – 2 wpi P = 0.003 P = 0.029 NS
  1. P-values were obtained using repeated measures analysis of variance (RM ANOVA) on 12 animals measured before infection and at 2 and 4 wpi. If significant by RM ANOVA, Holm's t-tests were used to isolate differences between the time points. Additionally, paired t-tests were performed on all 18 animals scanned before infection and 2 wpi. NS indicated that ANOVA or t-tests were not significant.
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