Table 1 C. elegans 5-HT mutants with respect to mammalian counterparts
From: Bilobalide modulates serotonin-controlled behaviors in the nematode Caenorhabditis elegans
C. elegans 5-HT mutants | Mammalian homologues | Gene product mechanisms | Function in C. elegans |
|---|---|---|---|
SER-4 | 5-HT1 receptors | ↓ levels of cAMP | Required for normal inhibition of movement by 5-HT and stimulation of egg-laying by imipramine |
SER-1 | 5-HT2 receptors | ↑ IP3, DAG, Ca2+ | Required for the stimulation of egg-laying by 5-HT and weakly for pharyngeal pumping |
MOD-5 | SLC6A4 | Na/Cl 5-HT transporter | Required for stimulation of egg-laying in by 5-HT |
TPH-1 | Tph1 | Tryptophan hydroxylase | Â |
MOD-1 | GABAB3 | 5-HT-gated Cl channels | Required for enhanced slowing response exhibited by food-deprived animals upon encountering a bacterial food source |