Figure 3
From: Nongenomic mechanisms of physiological estrogen-mediated dopamine efflux
3H-DA efflux assay after 9 min 10-9 M E 2 treatment in the presence of VMAT inhibitor. PC 12 cells were pretreated for 2 hrs with reserpine, a VMAT inhibitor, in order to inhibit vesicular release of DA, and then treated with 10-9 M E2 or ethanol (vehicle control). The Y-axis is % of 10-9 M E2 dopamine efflux response at 9 mins, dashed lines are errors around the mean. * = p < 0.05 significance compared to control, # = p < 0.05 vs. E2 treatment without reserpine. n = 18 in 3 experiments.