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Table 3 Levels of MMP-9 and TIMP-1 protein in brain tissue after MCAO and after treatment with U0126 at 0, 6, and 12 hours post occlusion

From: Enhanced cerebrovascular expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 via the MEK/ERK pathway during cerebral ischemia in the rat

Brain tissue

 

Control

MCAO

MCAO + U0126 - 0 h

MCAO + U0126 - 6 h

MCAO + U0126 - 12 h

MMP-9 (%) ± SEM

100 ± 5.8

125 ± 8.0

101 ± 6.5

102 ± 4.7

109 ± 7.2

TIMP-1 (%) ± SEM

100 ± 3.8

113 ± 2.7

111 ± 5

105 ± 2.7

112 ± 5.2

  1. Values are percentages of the control value and are reported as mean ± standard error of the mean (SEM); n = 5–6, *P < 0.05, **P < 0.01, §P < 0.05, §§ P < 0.01. *Indicates a significant difference between the control group and the MCAO group; § indicates a significant difference between the MCAO group and the U0126-treated group.
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BMC Neuroscience

ISSN: 1471-2202

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