TY - JOUR AU - Maddahi, Aida AU - Chen, Qingwen AU - Edvinsson, Lars PY - 2009 DA - 2009/06/04 TI - Enhanced cerebrovascular expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 via the MEK/ERK pathway during cerebral ischemia in the rat JO - BMC Neuroscience SP - 56 VL - 10 IS - 1 AB - Cerebral ischemia is usually characterized by a reduction in local blood flow and metabolism and by disruption of the blood-brain barrier in the infarct region. The formation of oedema and opening of the blood-brain barrier in stroke is associated with enhanced expression of metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1). SN - 1471-2202 UR - https://doi.org/10.1186/1471-2202-10-56 DO - 10.1186/1471-2202-10-56 ID - Maddahi2009 ER -