TY - JOUR AU - Rubinov, Mikail AU - Sporns, Olaf AU - van Leeuwen, Cees AU - Breakspear, Michael PY - 2009 DA - 2009/06/02 TI - Symbiotic relationship between brain structure and dynamics JO - BMC Neuroscience SP - 55 VL - 10 IS - 1 AB - Brain structure and dynamics are interdependent through processes such as activity-dependent neuroplasticity. In this study, we aim to theoretically examine this interdependence in a model of spontaneous cortical activity. To this end, we simulate spontaneous brain dynamics on structural connectivity networks, using coupled nonlinear maps. On slow time scales structural connectivity is gradually adjusted towards the resulting functional patterns via an unsupervised, activity-dependent rewiring rule. The present model has been previously shown to generate cortical-like, modular small-world structural topology from initially random connectivity. We provide further biophysical justification for this model and quantitatively characterize the relationship between structure, function and dynamics that accompanies the ensuing self-organization. SN - 1471-2202 UR - https://doi.org/10.1186/1471-2202-10-55 DO - 10.1186/1471-2202-10-55 ID - Rubinov2009 ER -