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Table 1 Brain areas with regional gray matter volume reductions in TS patients compared to normal subjects

From: Prefrontal and anterior cingulate cortex abnormalities in Tourette Syndrome: evidence from voxel-based morphometry and magnetization transfer imaging

Cluster size Regions (Brodmann areas) MNI-Space t-value p-value
(SVC)
   x y z   
254 Left postcentral gyrus (43) -55 -8 20 5.04 0.009
83 Right precentral gyrus (4) 38 -20 47 4.54 0.031
60 right cingulate gyrus (32) 9 22 31 4.01 0.049
224 Left caudate (body) -15 14 13 4.00 0.018
  Left caudate (head) -10 11 3 3.54  
57 Left middle frontal gyrus (6) -36 12 56 4.00 0.018
180 Left precentral gyrus (4) -45 -18 36 3.96 0.020
  Left precentral gyrus (4) -52 -15 40 3.52  
58 Right middle frontal gyrus (6) 44 6 57 3.96 0.020
152 Right precentral gyrus (6) 59 -13 38 3.95 0.020
43 Right precentral gyrus (4) 45 -19 38 3.95 0.017
25 Right postcentral gyrus (3) 41 -26 58 3.68 0.014
14 Right medial frontal gyrus (8) 10 29 48 3.62 0.042
20 Left cingulate gyrus (32) -9 12 39 3.61 0.043
  1. Cluster size = number of voxels; x, y, z = Coordinates (in mm) of significant local maxima are given for information in MNI space (Montreal Neurological Institute, http://www.bic.mni.mcgill.ca). Significant local maxima more than 8 mm apart were translated to brain anatomy by converting their coordinates from MNI space to Talairach space http://www.talairach.org/ allowing for a search radius of 9 mm for nearest gray matter. For regions where an effect was hypothesized (see introduction), a small volume correction (SVC) was performed. P values are given after family wise error (FWE) correction for the particular volume. No regions displayed significant regional increases in GMV for TS patients versus controls.