Areas with negative correlation between MTR maps and YGTSS score in TS patients. Areas with negative correlation between MTR maps and YGTSS score in TS patients. The same conventions apply as for figure 4. Significant voxels for MTR map reductions with higher YGTSS scores were found in right anterior cingulate gyrus, parietal-temporal-occipital association cortex, and superior frontal gyrus bilaterally (corrected P < .05). Note that changes in temporal areas, which were not significant according to our hypothesis, are also displayed. MTR = magnetization transfer ratio, YGTSS = Yale global tic severity scale, TS = Tourette syndrome.