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Table 1 Mean metabolic ratios in each animal group before and after donepezil and NaCl respectively.

From: In vivo 1H-magnetic resonance spectroscopy can detect metabolic changes in APP/PS1 mice after donepezil treatment

Mice type Brain region Treatment Gln/tCr Glu/tCr m-Ins/tCr Tau/tCr tCho/tCr tNAA/tCr
    Mean ± SD
tg str before 0.64 ± 0.11 1.30 ± 0.13 0.96 ± 0.11 1.28 ± 0.10 0.33 ± 0.03 0.90 ± 0.13
tg str donepezil 0.77 ± 0.28 1.27 ± 0.34 0.89 ± 0.11 0.97 ± 0.23 0.38 ± 0.01 0.93 ± 0.15
tg str NaCl 0.59 ± 0.07 1.47 ± 0.22 0.97 ± 0.13 1.29 ± 0.14 0.39 ± 0.03 0.99 ± 0.07
tg ctx/hipp before 0.61 ± 0.13 1.48 ± 0.26 0.62 ± 0.15 0.86 ± 0.10 0.24 ± 0.03 1.19 ± 0.11
tg ctx/hipp donepezil 0.72 ± 0.08 1.60 ± 0.30 0.57 ± 0.07 0.73 ± 0.07 0.24 ± 0.03 1.24 ± 0.20
tg ctx/hipp NaCl 0.72 ± 0.17 1.60 ± 0.23 0.55 ± 0.14 0.85 ± 0.13 0.25 ± 0.04 1.18 ± 0.21
wt str before 0.61 ± 0.14 1.18 ± 0.12 0.78 ± 0.09 1.14 ± 0.10 0.34 ± 0.02 0.88 ± 0.10
wt str donepezil 0.67 ± 0.11 1.34 ± 0.16 0.79 ± 0.12 1.22 ± 0.13 0.36 ± 0.02 0.93 ± 0.05
wt str NaCl 0.72 ± 0.10 1.25 ± 0.11 0.78 ± 0.09 1.21 ± 0.13 0.34 ± 0.03 0.90 ± 0.06
wt ctx/hipp before 0.46 ± 0.16 1.37 ± 0.14 0.52 ± 0.08 0.78 ± 0.08 0.22 ± 0.02 0.96 ± 0.09
wt ctx/hipp donepezil 0.49 ± 0.09 1.34 ± 0.11 0.52 ± 0.06 0.75 ± 0.09 0.24 ± 0.03 0.99 ± 0.11
wt ctx/hipp NaCl 0.46 ± 0.06 1.41 ± 0.20 0.52 ± 0.09 0.77 ± 0.09 0.22 ± 0.02 1.03 ± 0.10
  1. Abbreviations: Gln = Glutamine, Glu = Glutamate, Tau = Taurine, m-Ins= Myo-inositol, tCho = Choline-containing compounds, tNAA = N-acetylaspartate+N-acetylaspartylglutamate, wt = wild type mice, tg = APP/PS1 transgenic mice, ctx/hipp = parietal cortex/hippocampus, str = striatum.