Effects of NR1 splicing on NR1/NR3B-type excitatory glycine receptors

BMC Neuroscience

Table 1 Antagonistic block of glycine-induced currents of exemplary diheteromers

Agonist/antagonist (all conc. μM)	10 Gly/5 CNQX	10 Gly/100 KynA	150 Gly/100 KynA
block of glycine-induced current response in % ± SEM
NR1–3a/NR2B	10.3 ± 3.3	39.4 ± 1.6	47.5 ± 3.3
NR1–3b/NR2B	10.9 ± 5.8	29.4 ± 6.5	30.5 ± 5.1
block of glycine-induced current response in % ± SEM
NR1–3a/NR3B	87.1 ± 1.7	84.6 ± 1.3	-244.9 ± 48.5
NR1–3b/NR3B	84.4 ± 1.5	82.1 ± 1.5	-263.9 ± 60.9

Overview of the block of glycine-induced current responses by CNQX and kynurenic acid (KynA) for exemplary NMDAR subunit combinations. Differences between NR1a- and NR1b- containing diheteromers are not statistically significant. n = 5 for each combination.

ISSN: 1471-2202