Figure 1

Experimental set-up. (A). Illustration of real-time neuro-navigation that provided the location of each coil relative to the FDI target in bilateral M1 for accurate positioning. (B). Interhemispheric inhibition (IHI) was investigated bi-directionally: from the non-dominant to dominant motor cortex (green arrow) and from the dominant to non-dominant motor cortex (purple arrow). IHI is measured in the FDI muscle contralateral to the test stimulus (TS) in each case. The conditioning stimulus (CS) preceded the TS by 6, 8, 10, 12, 30, 40, 50 ms. IHI was tested in both directions during rest, isometric contraction of the FDI muscle (left or right) and isometric pen holding posture (left or right).