Figure 1

Micrographs showing expression of the transcription factor YB-1 in the rat, macaque and human brain (A-H). (A) Image displaying hippocampal YB-1 expression visualized by a DAB-staining method in a 14 μm thin section of an adult rat's hippocampus (DG = dentate gyrus, H = hilus of the dentate gyrus, CA = cornu ammonis formation). (B) Representative example of YB-1 expression in the piriform cortex (layer I-III) of an adult rat. Note, that the expression of YB-1 is predominantly related to cells in the layer III of the piriform cortex. (C) Image showing YB-1 expressing granule cells of the dentate gyrus and YB-1 expressing cells in the hilar (H) subregion of the hippocampus of an adult rat. (D) Image displaying YB-1 expression visualized by a DAB-staining method in a 14 μm thick section of the parahippocampal cortex (PHC) of a rat. YB-1 expression appears throughout all layers of the cortex. (E) Image displaying YB-1 expression visualized by a DAB-staining method in a 40 μm thick section of a macaque's parahippocampal cortex (PHC). In this image YB-1 appears to be stronger expressed as in the rat's brain due to the relative thickness of this section in comparison to the thinner sections of the rat. (F) Image displaying YB-1 expression visualized by a DAB-staining method in a 3 μm thin section of a human parahippocampal cortex (PHC). Due to the section thickness of only 3 μm, YB-1 appears to be less expressed compared to images of the rat's and macaque's brain. (G) Image displaying YB-1 expressing granule cells of the dentate gyrus (DG) as well as YB-1 expressing cells in the hilar (H) subregion and the molecular layer (Mol) of the hippocampal formation in the brain of a macaque. (H) YB-1 expression in the hippocampal CA-1 region of the human brain. A: scale bar = 100 μm. B-H: scale bar = 20 μm.