Figure 3

Abnormalities in cortical organization. Panel A: Photomicrograph of a Nissl stained section demonstrating the disorganization of the microgyrial cortex. The layered organization is irregular and anomalous, with the formation of small islets (arrow). Panel B: Photomicrograph showing the lack of lumen and of pia between two facing portions of cortex in a sulcus, resulting in the fusion of both layers I in a unique strip of white matter (black arrow). Panel C: Photomicrograph of a Nissl stained section showing the absence of well defined laminar organization. Panel D: Photomicrograph of a SMI-32 stained section adjacent to the section presented in panel C. Note that the SMI-32 positive neurons occupy positions in the cortex which vary strongly with regard of its distance to the cortex surface (black arrows). White arrows in panels C and D indicate the same blood vessels. Scale bars: 500 microns.