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Table 2 Pup hormonal profile

From: Developmental iodine deficiency resulting in hypothyroidism reduces hippocampal ERK1/2 and CREB in lactational and adolescent rats

Hormone Time Control 5 ppm-PTU 15 ppm-PTU ID
TSH (mUI/L) PN14 0.064 ± 0.029 1.713 ± 1.195 * 2.218 ± 0.587 * 0.142 ± 0.013
  PN21 0.052 ± 0.019 0.754 ± 0.538 * 1.990 ± 1.003 *# 0.246 ± 0.111 Δ
  PN28 0.077 ± 0.023 0.908 ± 1.030 * 2.329 ± 1.378 *# 0.129 ± 0.038 Δ
  PN42 0.074 ± 0.043 0.059 ± 0.031 0.065 ± 0.039 0.111 ± 0.049 *
FT3 (pmol/L) PN14 3.093 ± 1.384 2.097 ± 0.401 * 1.540 ± 0.000 * 1.555 ± 0.021 *
  PN21 7.250 ± 1.205 9.823 ± 5.322 3.649 ± 1.229 *# 1.985 ± 0.346 *#
  PN28 13.310 ± 0.924 12.399 ± 2.823 6.879 ± 3.621 *# 6.095 ± 3.828 *#
  PN42 12.696 ± 4.882 13.105 ± 3.192 10.947 ± 3.282 13.520 ± 1.596
FT4 (pmol/L) PN14 25.025 ± 6.060 7.997 ± 0.939 * 6.610 ± 0.935 * 8.850 ± 1.202 *
  PN21 33.225 ± 14.561 11.545 ± 6.173 * 10.000 ± 2.436 * 13.400 ± 0.707 *
  PN28 31.330 ± 6.527 10.968 ± 2.227 * 9.885 ± 2.184 * 12.430 ± 1.432 *
  PN42 41.155 ± 11.792 36.540 ± 7.826 41.150 ± 15.463 34.990 ± 9.212
  1. The circulating levels of TSH were increased in PTU-induced hypothyroidism pups, while there were no significant differences in iodine-deficient pups on PN14, PN21 and PN28. ID and PTU-induced hypothyroidism decreased the serum FT3 and FT4 levels on PN14, PN21 and PN28. On PN42, the concentrations of serum FT3, FT4 and TSH in iodine-deficient and PTU-treatment groups were restored gradually. Each values represents mean ± SEM (n = 8-10 for each group). *P < 0.05, as compared to control group. #P < 0.05, as compared to 5 ppm PTU-treatment group. ΔP < 0.05, as compared to 15 ppm PTU-treatment group.