Developmental iodine deficiency resulting in hypothyroidism reduces hippocampal ERK1/2 and CREB in lactational and adolescent rats

Table 2 Pup hormonal profile

Hormone	Time	Control	5 ppm-PTU	15 ppm-PTU	ID
TSH (mUI/L)	PN14	0.064 ± 0.029	1.713 ± 1.195 *	2.218 ± 0.587 *	0.142 ± 0.013 ^#Δ
	PN21	0.052 ± 0.019	0.754 ± 0.538 *	1.990 ± 1.003 *^#	0.246 ± 0.111 ^Δ
	PN28	0.077 ± 0.023	0.908 ± 1.030 *	2.329 ± 1.378 *^#	0.129 ± 0.038 ^Δ
	PN42	0.074 ± 0.043	0.059 ± 0.031	0.065 ± 0.039	0.111 ± 0.049 *^#Δ
FT3 (pmol/L)	PN14	3.093 ± 1.384	2.097 ± 0.401 *	1.540 ± 0.000 *	1.555 ± 0.021 *
	PN21	7.250 ± 1.205	9.823 ± 5.322	3.649 ± 1.229 *^#	1.985 ± 0.346 *^#
	PN28	13.310 ± 0.924	12.399 ± 2.823	6.879 ± 3.621 *^#	6.095 ± 3.828 *^#
	PN42	12.696 ± 4.882	13.105 ± 3.192	10.947 ± 3.282	13.520 ± 1.596
FT4 (pmol/L)	PN14	25.025 ± 6.060	7.997 ± 0.939 *	6.610 ± 0.935 *	8.850 ± 1.202 *
	PN21	33.225 ± 14.561	11.545 ± 6.173 *	10.000 ± 2.436 *	13.400 ± 0.707 *
	PN28	31.330 ± 6.527	10.968 ± 2.227 *	9.885 ± 2.184 *	12.430 ± 1.432 *
	PN42	41.155 ± 11.792	36.540 ± 7.826	41.150 ± 15.463	34.990 ± 9.212

The circulating levels of TSH were increased in PTU-induced hypothyroidism pups, while there were no significant differences in iodine-deficient pups on PN14, PN21 and PN28. ID and PTU-induced hypothyroidism decreased the serum FT₃ and FT₄ levels on PN14, PN21 and PN28. On PN42, the concentrations of serum FT₃, FT₄ and TSH in iodine-deficient and PTU-treatment groups were restored gradually. Each values represents mean ± SEM (n = 8-10 for each group). *P < 0.05, as compared to control group. ^#P < 0.05, as compared to 5 ppm PTU-treatment group. ^ΔP < 0.05, as compared to 15 ppm PTU-treatment group.

ISSN: 1471-2202