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Figure 1 | BMC Neuroscience

Figure 1

From: Activation of Retinoid X Receptor increases dopamine cell survival in models for Parkinson's disease

Figure 1

RXR ligands selectively rescue primary DA neurons from 6-OHDA-induced toxicity. A) Primary vMB cultures stained for TH-positive DA neurons (red arrow). 6-OHDA-exposure caused neurodegeneration, leaving cell debris (green arrow) and damaged neurites (green arrowhead). B) 6-OHDA produced a dose dependent toxicity of primary DA cells. 20 minutes exposure of 5, 10 and 15 μM 6-OHDA reduced the number of DA cells by 21%, 40% and 60%, respectively. C) In cultures stressed by 15 μM 6-OHDA, LG268 and the selective Nurr1-RXR ligand XCT rescued the DA neurons from degeneration. D) LG268 had no effects on the total amount of TuJ1-positive cells after 6-OHDA treatment. Stars (*) refer to differences between control-group (N2) and experimental-group, whereas values above brackets refer to differences between different experimental-groups. ns denotes non-significant, * denotes p < 0.05, ** denotes p < 0.01 and *** denotes p < 0.001 according to Tukey's multiple comparison test.

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