TY - JOUR AU - Draganova, Rossitza AU - Wollbrink, Andreas AU - Schulz, Matthias AU - Okamoto, Hidehiko AU - Pantev, Christo PY - 2009 DA - 2009/12/01 TI - Modulation of auditory evoked responses to spectral and temporal changes by behavioral discrimination training JO - BMC Neuroscience SP - 143 VL - 10 IS - 1 AB - Due to auditory experience, musicians have better auditory expertise than non-musicians. An increased neocortical activity during auditory oddball stimulation was observed in different studies for musicians and for non-musicians after discrimination training. This suggests a modification of synaptic strength among simultaneously active neurons due to the training. We used amplitude-modulated tones (AM) presented in an oddball sequence and manipulated their carrier or modulation frequencies. We investigated non-musicians in order to see if behavioral discrimination training could modify the neocortical activity generated by change detection of AM tone attributes (carrier or modulation frequency). Cortical evoked responses like N1 and mismatch negativity (MMN) triggered by sound changes were recorded by a whole head magnetoencephalographic system (MEG). We investigated (i) how the auditory cortex reacts to pitch difference (in carrier frequency) and changes in temporal features (modulation frequency) of AM tones and (ii) how discrimination training modulates the neuronal activity reflecting the transient auditory responses generated in the auditory cortex. SN - 1471-2202 UR - https://doi.org/10.1186/1471-2202-10-143 DO - 10.1186/1471-2202-10-143 ID - Draganova2009 ER -