The region of DG is resistant to ischemic damage while CA1 is vulnerable. Blockage activation of Src instead of ERK significantly decreased neuronal loss in hippocampal CA1 after ischemia. NISSL staining was performed to examine the survival of hippocampal neurons following 5 days reperfusion. (A) sham group, (B) 5 days of reperfusion postischemia (R5d), (C) SU6656 administration, (D) U0126 administration, and (E) vehicle administration (n = 5). Data are expressed as means ± S.D. *P < 0.05 versus sham; #P < 0.05 versus I/R 5 days groups (n = 5). Scale bars in A-E = 200 μm; bars in CA1 and DG = 20 μm.