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Figure 3 | BMC Neuroscience

Figure 3

From: Non-receptor tyrosine kinase Src is required for ischemia-stimulated neuronal cell proliferation via Raf/ERK/CREB activation in the dentate gyrus

Figure 3

Inhibition on activated ERK blocked ischemia-stimulated cell proliferation in the dentate gyrus and CREB activation, but it did not affect expression of p-Src and p-Raf. U0126 was intracerebroventricularly (i.c.v) administratered 20 min before ischemia. (A) ERK phosphorylation after reperfusion 24 h post ischemia.(B) DAB staining for BrdU-positive cells in the SGZ at the 7th post-ischemic day. (a) Rats with 7 days of reperfusion after ischemia (n = 5), (b) U0126-treated ischemic rats (n = 4), (c) vehicle-treated ischemic rats (n = 4), and (d) SU6656-treated ischemic rats (n = 5). (C) CREB phosphorylation, (D) Src phosphorylation or (E) Raf phosphorylation. Data are expressed as mean ± S.D. *P < 0.05 vs. sham, #P < 0.05 or aP < 0.05 vs. respective reperfusion. Bar: 200 μm

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