Table 3 Clustering of the genes whose expression is altered in the choroid plexus upon repeated peripheral LPS injection.
From: The choroid plexus response to a repeated peripheral inflammatory stimulus
Atered genes | |||
|---|---|---|---|
3 days | 15 days | ||
Signaling pathways | Toll like receptor signaling | Tlr7; Mapk8; Cd14; Relb ↑ | - |
T cell receptor signaling | Mapk8; Nfat5;Btk; Vav1; Relb ↑; Rras2; Nfatc1 ↓ | Itk ↑ | |
B cell receptor signaling | Fcgr2a; Bcl2a1; Mapk8; Nfat5; Map2k7; Rac2; Fcgr2b; Inpp5d; Btk; Vav1; Relb ↑; Rras2; Nfatc1; Bcl2l1 ↓ | - | |
SAPK JNK signaling | Gpr65; Gpr24; Mapk8; Map2k7; Rac2; Sh2d2a ↑; Rras2; Fadd; Nfatc1; Egfr ↓ | Gng11;Gpr34 ↑; Dusp8 ↓ | |
Natural killer signaling | Fcer1g; Tyrobp; Siglec7; Rac2; Klrd1; Inpp5d; Vav1; Hcst ↑; Rras2 ↓ | Klrd1; Siglec7 ↑ | |
NF-kB signaling | Tlr7; Tnfsf13b; Mapk8; Map2k7; Relb ↑; Rras2; Egf; Tnfsf11; Egfr ↓ | Tnfsf13b ↑ | |
JAK/STAT signaling | Stat3 ↑; Rras2 ↓ | - | |
cAMP mediated signaling | Rgs10; Grm3; Stat3 ↑; Gnai; Grk4; Cngb1; Rgs12 ↓ | Adcy9; Crem ↓ | |
Interferon signaling | Isgf3g; Tap1; Ifngr2; Ifitm1; Ifitm3; Ifi205; Irf5; Ifngr2 ↑ | Ifitm1 ↑ | |
GM-CSF signaling | Bcl2a1; Stat3 ↑; Rras2; Bcl2l1 ↓ | - | |
Integrin signaling | Mapk8; Actin4; Rac2 ↑; Rras2; Egfr ↓ | Itgae; Itgb7 ↑ | |
IL-10 signaling | Il10ra; Tcgr2a; Mapk8; Cd14; Fcgr2b; Stat3; Relb ↑ | - | |
IL-6 signaling | Mapk8; Map2k7; Cd14; Stat3; Relb ↑; Rras2 ↓ | - | |
IL-4 signaling | Nfat5; Il2rg; Inpp5d ↑; Rras2; Nfatc1 ↓ | - | |
IL-2 signaling | Mapk8; Il2rg ↑; Rras2 ↓ | - | |
Complement/coagulation cascade signaling | C3; C1qa; C1qb; C1qg; Vwf; Serping1; C2 ↑ | Serpind1; C1qg; C1qa; C3 ↓ | |
Apoptosis signaling | Casp1; Bcl2a1; Mapk8; Map2k7; Relb ↑; Rras2; Bcl2l1; Ecfr; Bcl2 ↓ | Card14 ↑ | |
Antigen presentation pathway | B2m; H2-T23; Tap1; Psmb9 ↑ | - | |
Acute phase response | Acute phase proteins | Serping1; Map2k7; C3; Mapk8;Saa3;Vwf; Stat3; Slp; C2; serpina3n ↑; Fn1; Rras2 ↓ | C3 ↑ |
Leukocyte migration | Leukocyte extravasation signaling | Ncf2; Selpl; Mapk8; Cyba; Jam2; Actn4; Rac2; Mmp23; Icam1; Glycam1; Madcam1; Timp1; Btk; Vav1 ↑; Gnai ↓ | Icam1; Itk; Cyba ↑ |
Extracellular matrix | Timp1; Dcn; Lamb2; Fbln1; Mmp23; Tecta; Emid1 ↑; Fn1 ↓ | Tnc; Spon2 ↓ | |
Cytokine signaling | Il16; Ccl5; Cxcl1; Ccl7; Ccl13; Xcl1; Cxcl16; Ccl2 ↑; Gnai1; Rras2 ↓ | Cxcl1; Ccl7; Xcl1; Ccl2 ↑ | |
Actin cytoskeleton signaling | Nckap1l; Gpr65; Gpr34; Actn4; Kng1; Rac2; Cd14; Vav1 ↑; Rras2; Fgf7; Egf; Myh14; Fn1; Egfr ↓ | Gpr34 ↑ | |
Axonal guidance signaling | Igf1; Nfat5; Rac2; Fes ↑; Gnai1; Slit2; Rras2; Rgma; Nfatc1; Egf; Egfr ↓ | Rgmb ↑ | |