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Table 3 Clustering of the genes whose expression is altered in the choroid plexus upon repeated peripheral LPS injection.

From: The choroid plexus response to a repeated peripheral inflammatory stimulus

Atered genes
   3 days 15 days
Signaling pathways Toll like receptor signaling Tlr7; Mapk8; Cd14; Relb ↑ -
  T cell receptor signaling Mapk8; Nfat5;Btk; Vav1; Relb ↑; Rras2; Nfatc1 ↓ Itk ↑
  B cell receptor signaling Fcgr2a; Bcl2a1; Mapk8; Nfat5; Map2k7; Rac2; Fcgr2b; Inpp5d; Btk; Vav1; Relb ↑; Rras2; Nfatc1; Bcl2l1 ↓ -
  SAPK JNK signaling Gpr65; Gpr24; Mapk8; Map2k7; Rac2; Sh2d2a ↑; Rras2; Fadd; Nfatc1; Egfr ↓ Gng11;Gpr34 ↑; Dusp8 ↓
  Natural killer signaling Fcer1g; Tyrobp; Siglec7; Rac2; Klrd1; Inpp5d; Vav1; Hcst ↑; Rras2 ↓ Klrd1; Siglec7 ↑
  NF-kB signaling Tlr7; Tnfsf13b; Mapk8; Map2k7; Relb ↑; Rras2; Egf; Tnfsf11; Egfr ↓ Tnfsf13b ↑
  JAK/STAT signaling Stat3 ↑; Rras2 ↓ -
  cAMP mediated signaling Rgs10; Grm3; Stat3 ↑; Gnai; Grk4; Cngb1; Rgs12 ↓ Adcy9; Crem ↓
  Interferon signaling Isgf3g; Tap1; Ifngr2; Ifitm1; Ifitm3; Ifi205; Irf5; Ifngr2 ↑ Ifitm1 ↑
  GM-CSF signaling Bcl2a1; Stat3 ↑; Rras2; Bcl2l1 ↓ -
  Integrin signaling Mapk8; Actin4; Rac2 ↑; Rras2; Egfr ↓ Itgae; Itgb7 ↑
  IL-10 signaling Il10ra; Tcgr2a; Mapk8; Cd14; Fcgr2b; Stat3; Relb ↑ -
  IL-6 signaling Mapk8; Map2k7; Cd14; Stat3; Relb ↑; Rras2 ↓ -
  IL-4 signaling Nfat5; Il2rg; Inpp5d ↑; Rras2; Nfatc1 ↓ -
  IL-2 signaling Mapk8; Il2rg ↑; Rras2 ↓ -
  Complement/coagulation cascade signaling C3; C1qa; C1qb; C1qg; Vwf; Serping1; C2 ↑ Serpind1; C1qg; C1qa; C3 ↓
  Apoptosis signaling Casp1; Bcl2a1; Mapk8; Map2k7; Relb ↑; Rras2; Bcl2l1; Ecfr; Bcl2 ↓ Card14 ↑
  Antigen presentation pathway B2m; H2-T23; Tap1; Psmb9 ↑ -
Acute phase response Acute phase proteins Serping1; Map2k7; C3; Mapk8;Saa3;Vwf; Stat3; Slp; C2; serpina3n ↑; Fn1; Rras2 ↓ C3 ↑
Leukocyte migration Leukocyte extravasation signaling Ncf2; Selpl; Mapk8; Cyba; Jam2; Actn4; Rac2; Mmp23; Icam1; Glycam1; Madcam1; Timp1; Btk; Vav1 ↑; Gnai ↓ Icam1; Itk; Cyba ↑
  Extracellular matrix Timp1; Dcn; Lamb2; Fbln1; Mmp23; Tecta; Emid1 ↑; Fn1 ↓ Tnc; Spon2 ↓
  Cytokine signaling Il16; Ccl5; Cxcl1; Ccl7; Ccl13; Xcl1; Cxcl16; Ccl2 ↑; Gnai1; Rras2 ↓ Cxcl1; Ccl7; Xcl1; Ccl2 ↑
  Actin cytoskeleton signaling Nckap1l; Gpr65; Gpr34; Actn4; Kng1; Rac2; Cd14; Vav1 ↑; Rras2; Fgf7; Egf; Myh14; Fn1; Egfr ↓ Gpr34 ↑
  Axonal guidance signaling Igf1; Nfat5; Rac2; Fes ↑; Gnai1; Slit2; Rras2; Rgma; Nfatc1; Egf; Egfr ↓ Rgmb ↑