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Figure 10 | BMC Neuroscience

Figure 10

From: Progranulin is expressed within motor neurons and promotes neuronal cell survival

Figure 10

PGRN over-expression in NSC-34 cells promotes a neuronal morphology. Untransfected NSC-34 cells (A-D), transfected with pcDNA3 vector only (E-H) or transfected with pcDNA3-hPGRN (I-L). Micrographs showing the distribution of DAPI (A, E, I), F-actin (B, F, J), hPGRN (C, G, K) and merged images (D, H, L). PGRN over-expression promotes more extensive cytoskeletal extensions (hatched box) and is localized within presumptive secretory granules (arrowheads).

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