Figure 10
From: Progranulin is expressed within motor neurons and promotes neuronal cell survival
PGRN over-expression in NSC-34 cells promotes a neuronal morphology. Untransfected NSC-34 cells (A-D), transfected with pcDNA3 vector only (E-H) or transfected with pcDNA3-hPGRN (I-L). Micrographs showing the distribution of DAPI (A, E, I), F-actin (B, F, J), hPGRN (C, G, K) and merged images (D, H, L). PGRN over-expression promotes more extensive cytoskeletal extensions (hatched box) and is localized within presumptive secretory granules (arrowheads).