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Table 4 Risk factors for MCI and AD. Logistic regression models.

From: The COMT Val158 Met polymorphism as an associated risk factor for Alzheimer disease and mild cognitive impairment in APOE 4 carriers

  MCI AD
Independent effects OR IC95% P OR IC95% p
G (+) NO E4 (+) a 0.90 (0.53-1.51) 0.68 1.24 (0.74-2.08) 0.42
E4 (+) b 2.53 (1.69-3.79) <0.001 4.37 (3.02-6.33) <0.001
E4 (+)*Women b1 2.46 (1.45-4.15) <0.001 5.10 (3.20-8.13) <0.001
E4 (+)*Men b2 2.59 (1.36-4.92) 0.04 3.19 (1.72-5.91) <0.001
E4 (+) NO COMT_G b3 1.64 (0.80-3.36) 0.18 2.61 (1.31-5.18) <0.01
  MCI AD
Synergistic effects OR IC95% p OR IC95% p
E4 (+) * GG c 2.11 (0.90-4.95) 0.08 5.96 (2.74-12.94) <0.001
E4 (+) * AG c 3.21 (1.56-6.63) 0.02 6.71 (3.36-13.41) <0.001
E4 (+) * GG * WOMEN d 2.00 (0.60-6.67) 0.26 11.50 (3.83-34.53) <0.001
E4 (+) * GG * MEN d 3.30 (0.88-12.35) 0.07 2.14 (0.64-7.20) 0.22
E4 (+) * AG * WOMEN d 2.40 (0.96-6.00) 0.06 7.94 (3.24-19.42) <0.001
E4 (+) * AG * MEN d 5.88 (1.69-20.42) <0.01 5.36 (1.76-16.28) <0.01
  1. a Sample selected by at least one COMT genotype and absence of E4. Reference category was sample control. b Total sample with any exclusion, control sample was reference. b1 Total sample with any exclusion, female control sample was reference. b2 Total sample with any exclusion, male control sample was reference. b3Sample selected by at least one E4 and none COMT G allele. Reference category was sample control. c Sample selected by at least one E4 and COMT genotype. d Sample selected by at least one E4, COMT genotype and gender. *In all cases, reference category was control sample.