Figure 5
From: A secretory phospholipase A2-mediated neuroprotection and anti-apoptosis
Microarray analysis on the endogenous phospholipases. (a) Hierachical clustering of all the phospholipases detected in our global gene expression studies. Signal log(2) ratio (vs normal control) of the average signal intensities (detection p value < 0.01) were used to construct the dendrogram and the genes and samples were clustered based on Euclidean distance and average linkage method (TIGR MultiExperiment Viewer; [52]). (b) expression of endogenous phospholipases at 24 hour reperfusion (c) expression of endogenous phospholipases at 48 hour reperfusion. Control, sham operated rat brain; MCAo, rats subjected to middle cerebral artery occlusion and reperfused for either 24 hr or 48 hr; PLA, MCAo rat administered with nPLA (0.15 μg/g rats) and allowed reperfusion for 24 hr or 48 hr.