Table 2 Biological pathways significantly enriched with differentially expressed genes
Biological pathways | Z score | Permute P | Associated Genes |
|---|---|---|---|
For genes expressed at higher levels in neurons vulnerable to OS | |||
mRNA processing reactome | 5.708 | 0 | Cugbp1, Dhx16, Hnrpa1, Hnrpa3, Hnrph1, Hnrpu, Mettl3, Nsep1, Rnpc2, Sfrs3, Sf3b1 |
Pyrimidine metabolism | 3.921 | 0.008 | Nt5e, Pold1, Tyms |
Alanine and aspartate metabolism | 3.265 | 0.021 | Gpt1, Got2 |
For genes expressed at higher levels in neurons resistant to OS | |||
MAPK cascade | 6.016 | 0 | Araf, Hras, Map2k1, Mapk1, Mapk10, Mbp, Jun |
Citrate (or TCA) cycle | 3.897 | 0.006 | Acly, Idh1, Idh3a |
Regulation of actin cytoskeleton | 2.524 | 0.014 | Enah, Fgf13, Fgfr2, Chrm3, Gna12, Hras, Map2k1, Mapk1, Pak3, Pip5k1c, Slc9a1 |
Prostaglandin synthesis regulation | 3.315 | 0.015 | Anxa4, Anxa5, Anxa6, Ptgs2, Hpgd |
Wnt signaling | 2.882 | 0.020 | Ccnd2, Jun, Mapk10, Prkce, Wnt2b |
Insulin signaling | 2.136 | 0.035 | Cap1, Gyg1, Hras, Igf1r, Jun, Map2k1, Mapk1, Mapk10, Pten, Sgk |
G protein signaling | 2.154 | 0.041 | Akap13, Akap6, Gna12, Gng8, Hras1, Prkce, Slc9a1 |