Table 1 Gene Ontology (GO) terms significantly enriched with differentially expressed genes
GO terms and accession numbers | Category* | Z score | Permute P | Associated Genes |
|---|---|---|---|---|
For genes expressed at higher levels in neurons vulnerable to OS | ||||
DNA repair (GO:0006281) | BP | 4.684 | 0.001 | Hmgb2, Cspg6, Pold1, Tyms, Xab2 |
Response to DNA damage stimulus (GO:0006974) | BP | 4.488 | 0.002 | Hmgb2, Cspg6, Pold1, Tyms, Xab2 |
Regulation of transcription (GO:0045449) | BP | 2.395 | 0.011 | Cnot2, Cbx7, Cebpe, Ctcf, E2f5, Gmeb2, Hif1a, Nfyc, Nr3c1, Pnrc1, Pou2f1, Rere, Rnpc2, Usf2, Zfp57 |
Intramolecular oxidoreductase activity (GO:0016860) | MF | 3.165 | 0.040 | Pdia3, Ebp |
For genes expressed at higher levels in neurons resistant to OS | ||||
Calcium- and calmodulin-dependent protein kinase activity (GO:0004685) | MF | 5.475 | 0 | Camk2a, Camkk1, Camk1b |
Energy derivation by oxidation of organic compounds (GO:0015980) | BP | 2.839 | 0.004 | Idh3a, Gyg1, Eno1, Pfkp, Ldha, Me1, Idh1 |
Neurotransmitter transport (GO:0006836) | BP | 3.313 | 0.008 | Cplx2, Rims2, Slc6a7, Slc6a9, Stx1a |
Main pathways of carbohydrate metabolism (GO:0006092) | BP | 2.739 | 0.010 | Eno1, Pfkp, Ldha, Idh3a, Me1, Idhc |
Synaptic vesicle (GO:0008021) | CC | 2.96 | 0.012 | Sept5, Syn2, Syp, Syt5 |
Regulation of neurotransmitter secretion (GO:0046928) | BP | 3.902 | 0.022 | Kcnmb4, Syn2 |
Regulation of action potential (GO:0001508) | BP | 3.902 | 0.022 | Kcnmb4, Pllp |
Regulation of signal transduction (GO:0009966) | BP | 2.858 | 0.025 | Igfbp3, Rgs14, Rgs3, Socs2 |