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Figure 5 | BMC Neuroscience

Figure 5

From: Ontogeny of ATP hydrolysis and isoform expression of the Plasma Membrane Ca2+-ATPase in mouse brain

Figure 5

Localization of PMCA isoforms in developing cerebellar cortex. At P0, PMCA1 was weakly expressed in cerebellar neural precursors, and from P8 it was located mainly in the neuropil of molecular layer (ml, asterisk). PMCA2 showed high expression levels from P0, being associated to developing Purkinje cells, with a clear localization in the plasma membrane of soma (arrowhead) and dendritic tree (asterisk). PMCA3 showed similar distribution pattern than PMCA1 but with stronger immunoreaction. In contrast, PMCA4 was expressed in the soma of Purkinje cells (arrowheads) from P15, and also in main dendrites at P30 (large arrow). In the granular layer (gl) at P30 stage, while in mature granule cells only were found PMCA1 and 3 (open arrowhead), all isoforms were expressed in cerebellar glomeruli (short arrow). Pcl, Purkinje cell layer. Scale bar: 50 μm.

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