Protective effect of transgenic expression of porcine heat shock protein 70 on hypothalamic ischemic and oxidative damage in a mouse model of heatstroke

Table 5 Hypothalamic levels of glutathione peroxidase, glutathione reductase and ATP obtained from non-heated [-]HSP72 ([-]HSP-N) mice, non-heated [+]HSP72 ([+]HSP72-N) mice, heated [-]HSP72 ([-]HSP72-H) mice, and heated [+]HSP72 ([+]HSP72-H) mice.

Treatment Groups	Glutathione peroxidase (mU/mg protein)	Glutathione reductase (mU/mg protein)	ATP (pmoles/mg wet wt)
[-]HSP72-N	345 ± 46	177 ± 18	38 ± 6
[+]HSP72-N	362 ± 51	165 ± 17	44 ± 5
[-]HSP72-H	108 ± 29^a	99 ± 14^a	16 ± 4^a
[+]HSP72-H	367 ± 58^b	166 ± 21^b	40 ± 7^b

Samples were measured 4 h post whole body heating for heated groups or the equivalent time period for the non-heated groups. ^aCompared with non-heated groups (P < 0.05); ^bCompared with [-]HSP72-H group (P < 0.05). Data are means ± S.E.M. of 12 mice per group.

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