Protective effect of transgenic expression of porcine heat shock protein 70 on hypothalamic ischemic and oxidative damage in a mouse model of heatstroke

Table 2 The concentrations of glutamate, glycerol, lactate/pyruvate ratio, DHBA, and nitrite in the extracellular levels of the hypothalamus obtained from non-heated [-]HSP72 ([-]HSP72-N) mice, non-heated [+]HSP72 ([+]HSP72-N) mice, heated [-]HSP72 ([-]HSP72-H) mice, and heated [+]HSP72 ([+]HSP72-H) mice.

Treatment Groups	Glutamate (% of baseline)	Lactate/pyruvate ratio	Glycerol (% of baseline)	Nitrite (μM)	DHBA (% of baseline)
[-]HSP72-N	100 ± 3	9 ± 1	102 ± 3	14 ± 2	100 ± 5
[+]HSP72-N	100 ± 2	8 ± 2	101 ± 2	15 ± 3	101 ± 6
[-]HSP72-H	178 ± 9^a	213 ± 14^a	156 ± 7^a	98 ± 9^a	142 ± 7^a
[+]HSP72-H	108 ± 6^b	25 ± 4^b	21 ± 3^b	26 ± 4^b	109 ± 6^b

Samples were measured 4 h post whole body heating or the equivalent time period for non-heated groups. ^aCompared with non-heated groups (P < 0.05); ^bCompared with [-]HSP72-H group (P < 0.05). Data are means ± S.E.M. of 12 mice per group.

ISSN: 1471-2202