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Table 1 Plasma concentrations of caffeine and its metabolite theophylline in caffeine-treated rats.

From: Regulation of cerebrospinal fluid production by caffeine consumption

  Caffeine (μg/ml) Theophylline (μg/ml)
Caffeine-treated rats with ventriculomegaly 0.037 ± 0.008 0.68 ± 0.089
Caffeine-treated rats without ventriculomegaly 0.010 ± 0.006 0.34 ± 0.174
  1. Rats were treated with caffeine (0.6 g/L) for 3 weeks and were sacrificed 3 days after MRI imaging. Means ± SEM of 10 rats in each group