| COX-2 +/+ | COX-2 -/- |
---|
Brain Region | Uninjured | Injured | Uninjured | Injured |
---|
CA1 | 3.22 ± 0.82 | 3.88 ± 0.47* | 2.97 ± 0.61 | 4.89 ± 1.43*†|
CTX | 2.72 ± 0.43 | 4.05 ± 0.87* | 2.77 ± 0.42 | 4.09 ± 0.70* |
DLG | 2.28 ± 0.20 | 3.36 ± 0.84* | 2.24 ± 0.31 | 3.40 ± 0.66* |
LPM | 2.51 ± 0.23 | 3.40 ± 0.62* | 2.52 ± 0.30 | 3.68 ± 0.92* |
DG | 4.66 ± 1.17 | 5.87 ± 0.80* | 4.36 ± 0.96 | 6.63 ± 1.59*†|
VPL/VPM | 2.02 ± 0.14 | 2.41 ± 0.20* | 1.97 ± 0.25 | 2.45 ± 0.41* |
- Binding studies conducted on mice euthanatized 9 days after injury. Data is expressed as mean ± SD of μCi/mg of wet tissue. * represents significant changes compared to the uninjured hemisphere; †represents significant changes compared to the corresponding hemisphere of the COX-2 +/+ animals. CA1, CA1 region of the hippocampus; CTX, cortex; DLG, dorsal lateral geniculate nucleus; LPM, lateral posterior nucleus; DG, dentate gyrus; VPL/VPM, ventral posteriolateral/medial thalamic nucleus.