Skip to main content

Table 2 Binding of [3H]-PK11195 following cortical contusion injury in COX-2 +/+ and COX-2 -/- mice.

From: Effects of genetic deficiency of cyclooxygenase-1 or cyclooxygenase-2 on functional and histological outcomes following traumatic brain injury in mice

  COX-2 +/+ COX-2 -/-
Brain Region Uninjured Injured Uninjured Injured
CA1 3.22 ± 0.82 3.88 ± 0.47* 2.97 ± 0.61 4.89 ± 1.43*†
CTX 2.72 ± 0.43 4.05 ± 0.87* 2.77 ± 0.42 4.09 ± 0.70*
DLG 2.28 ± 0.20 3.36 ± 0.84* 2.24 ± 0.31 3.40 ± 0.66*
LPM 2.51 ± 0.23 3.40 ± 0.62* 2.52 ± 0.30 3.68 ± 0.92*
DG 4.66 ± 1.17 5.87 ± 0.80* 4.36 ± 0.96 6.63 ± 1.59*†
VPL/VPM 2.02 ± 0.14 2.41 ± 0.20* 1.97 ± 0.25 2.45 ± 0.41*
  1. Binding studies conducted on mice euthanatized 9 days after injury. Data is expressed as mean ± SD of μCi/mg of wet tissue. * represents significant changes compared to the uninjured hemisphere; † represents significant changes compared to the corresponding hemisphere of the COX-2 +/+ animals. CA1, CA1 region of the hippocampus; CTX, cortex; DLG, dorsal lateral geniculate nucleus; LPM, lateral posterior nucleus; DG, dentate gyrus; VPL/VPM, ventral posteriolateral/medial thalamic nucleus.