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Table 1 Binding of [3H]-PK11195 following cortical contusion injury in COX-1 +/+ and COX-1 -/- mice.

From: Effects of genetic deficiency of cyclooxygenase-1 or cyclooxygenase-2 on functional and histological outcomes following traumatic brain injury in mice

 

COX-1 +/+

COX-1 -/-

Brain Region

Uninjured

Injured

Uninjured

Injured

CA1

5.35 ± 0.97

5.55 ± 1.07

3.71 ± 0.50†

4.46 ± 0.38*†

CTX

3.01 ± 0.23

3.63 ± 0.70

2.95 ± 0.22

3.36 ± 0.35

DLG

2.65 ± 0.18

4.09 ± 0.79*

2.48 ± 0.14

4.15 ± 1.10*

LPM

2.83 ± 0.15

3.72 ± 0.41*

2.66 ± 0.26

3.87 ± 0.85*

DG

5.00 ± 1.58

7.15 ± 2.52*

4.66 ± 0.54

6.59 ± 0.78*

VPL/VPM

2.16 ± 0.14

2.56 ± 0.27*

2.07 ± 0.18

2.54 ± 0.40*

  1. Binding studies conducted on mice euthanatized 9 days after injury. Data is expressed as mean ± SD of μCi/mg of wet tissue. * represents significant changes compared to the uninjured hemispere; † represents significant changes compared to the corresponding hemisphere of the COX-1 +/+ animals. CA1, CA1 region of the hippocampus; CTX, cortex; DLG, dorsal lateral geniculate nucleus; LPM, lateral posterior nucleus; DG, dentate gyrus; VPL/VPM, ventral posteriolateral/medial thalamic nucleus.