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Table 1 Binding of [3H]-PK11195 following cortical contusion injury in COX-1 +/+ and COX-1 -/- mice.

From: Effects of genetic deficiency of cyclooxygenase-1 or cyclooxygenase-2 on functional and histological outcomes following traumatic brain injury in mice

  COX-1 +/+ COX-1 -/-
Brain Region Uninjured Injured Uninjured Injured
CA1 5.35 ± 0.97 5.55 ± 1.07 3.71 ± 0.50 4.46 ± 0.38*
CTX 3.01 ± 0.23 3.63 ± 0.70 2.95 ± 0.22 3.36 ± 0.35
DLG 2.65 ± 0.18 4.09 ± 0.79* 2.48 ± 0.14 4.15 ± 1.10*
LPM 2.83 ± 0.15 3.72 ± 0.41* 2.66 ± 0.26 3.87 ± 0.85*
DG 5.00 ± 1.58 7.15 ± 2.52* 4.66 ± 0.54 6.59 ± 0.78*
VPL/VPM 2.16 ± 0.14 2.56 ± 0.27* 2.07 ± 0.18 2.54 ± 0.40*
  1. Binding studies conducted on mice euthanatized 9 days after injury. Data is expressed as mean ± SD of μCi/mg of wet tissue. * represents significant changes compared to the uninjured hemispere; † represents significant changes compared to the corresponding hemisphere of the COX-1 +/+ animals. CA1, CA1 region of the hippocampus; CTX, cortex; DLG, dorsal lateral geniculate nucleus; LPM, lateral posterior nucleus; DG, dentate gyrus; VPL/VPM, ventral posteriolateral/medial thalamic nucleus.