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Transcranial ultrasound stimulation and its applications in neurosciences

Editors: Shanbao Tong Shanghai Jiao Tong University and Junfeng Sun Shanghai Jiao Tong University

Different modalities of neuromodulation, e.g., magnetic, electrical, acoustic, optical, and even thermal stimulation, have been proposed and applied in basic and clinical neurosciences. Transcranial ultrasound stimulation (TUS) is an emerging technique in past few years. TUS could noninvasively excite or inhibit the neural activities in the targeted brain regions by delivering specific low intensity and low frequency (around 0.5 MHz) pulsed ultrasonic waves through intact scalp and skull. With focused transducer, TUS could gain higher focality (~mm) and more depth (>2cm) than transcranial magnetic stimulation (TMS) and transcranial direct current stimula¬tion (tDCS). With these advantages, TUS would be a very useful and noninvasive tool to modulate specific neuronal pathways or neuclei in both clinical and basic neurosciences. TUS also has demonstrated its potential therapeutic effect on neurologic diseases (i.e. Alzheimer's Disease, epilepsy, and stroke). 

This thematic series if calling for contributions on the TUS techniques and applications, including but not limited to
•    TUS system and navigation
•    Monitoring techniques for the excitatory and inhibitory effects of TUS
•    Neuromodulation effects of TUS 
•    Optimal parameters of TUS
•    Safety issues of TUS
•    Therapeutic effects of TUS on disease animal model 
•    The mechanisms of TUS 
•    Applications of TUS in cognitive brain function
•    Clinical studies of TUS

We welcome submissions of research articles and opinion pieces focused the techniques, applications and effects of TUS.

If you have any research you would like us to consider please submit directly to BMC Neuroscience.  Alternatively you can email you presubmission queries to Ben Ragen (

The deadline for submissions of manuscripts is 1st August 2018. 

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