Volume 7 Supplement 1

Problems and tools in the systems biology of the neuronal cell


Edited by Sergio Nasi, Ivan Arisi, Antonino Cattaneo, Marta Cascante

  1. Review

    Rules of engagement promote polarity in RNA trafficking

    Many cell biological pathways exhibit overall polarity (net movement of molecules in one direction) even though individual molecular interactions in the pathway are freely reversible. The A2 RNA trafficking pa...

    John H Carson, Nicholas Blondin and George Korza

    BMC Neuroscience 2006 7(Suppl 1):S3

    Published on: 30 October 2006

  2. Review

    Synaptic proteins as multi-sensor devices of neurotransmission

    Neuronal communication is tightly regulated in time and space. Following neuronal activation, an electrical signal triggers neurotransmitter (NT) release at the active zone. The process starts by the signal re...

    Guy Brachya, Chava Yanay and Michal Linial

    BMC Neuroscience 2006 7(Suppl 1):S4

    Published on: 30 October 2006

  3. Review

    Non coding RNA and brain

    Small non coding RNAs are a group of very different RNA molecules, present in virtually all cells, with a wide spectrum of regulatory functions which include RNA modification and regulation of protein synthesi...

    Carlo Presutti, Jessica Rosati, Sara Vincenti and Sergio Nasi

    BMC Neuroscience 2006 7(Suppl 1):S5

    Published on: 30 October 2006

  4. Review

    Parameter estimate of signal transduction pathways

    The "inverse" problem is related to the determination of unknown causes on the bases of the observation of their effects. This is the opposite of the corresponding "direct" problem, which relates to the predic...

    Ivan Arisi, Antonino Cattaneo and Vittorio Rosato

    BMC Neuroscience 2006 7(Suppl 1):S6

    Published on: 30 October 2006

  5. Review

    Integration of enzyme kinetic models and isotopomer distribution analysis for studies of in situcell operation

    A current trend in neuroscience research is the use of stable isotope tracers in order to address metabolic processes in vivo. The tracers produce a huge number of metabolite forms that differ according to the nu...

    Vitaly A Selivanov, Tatiana Sukhomlin, Josep J Centelles, Paul WN Lee and Marta Cascante

    BMC Neuroscience 2006 7(Suppl 1):S7

    Published on: 30 October 2006

  6. Review

    Mathematical modeling of intracellular signaling pathways

    Dynamic modeling and simulation of signal transduction pathways is an important topic in systems biology and is obtaining growing attention from researchers with experimental or theoretical background. Here we...

    Edda Klipp and Wolfram Liebermeister

    BMC Neuroscience 2006 7(Suppl 1):S10

    Published on: 30 October 2006

  7. Review

    Model storage, exchange and integration

    The field of Computational Systems Neurobiology is maturing quickly. If one wants it to fulfil its central role in the new Integrative Neurobiology, the reuse of quantitative models needs to be facilitated. Th...

    Nicolas Le Novère

    BMC Neuroscience 2006 7(Suppl 1):S11

    Published on: 30 October 2006