Neurobiology of disease

Section edited by Karsten Ruscher

This section covers the neurobiological aspects of diseases that can affect the brain. Topics of interest include, but are not limited to, neurodegenerative pathophysiology, neurogenesis and experimental brain research. Diseases range across neurodegeneration, demyelinating conditions, ischemia and spinal cord conditions.

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  1. Research article

    Early start of progressive motor deficits in Line 61 α-synuclein transgenic mice

    Synucleinopathies such as Parkinson’s disease or multiple system atrophy are characterized by Lewy bodies in distinct brain areas. These aggregates are mainly formed by α-synuclein inclusions, a protein crucia...

    R. Rabl, C. Breitschaedel, S. Flunkert, S. Duller, D. Amschl, J. Neddens, V. Niederkofler, E. Rockenstein, E. Masliah, H. Roemer and B. Hutter-Paier

    BMC Neuroscience 2017 18:22

    Published on: 31 January 2017

  2. Research article

    TDP-43 protein variants as biomarkers in amyotrophic lateral sclerosis

    TDP-43 aggregates accumulate in individuals affected by amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases, representing potential diagnostic and therapeutic targets. Using an atomic forc...

    Stephanie M. Williams, Galam Khan, Brent T. Harris, John Ravits and Michael R. Sierks

    BMC Neuroscience 2017 18:20

    Published on: 25 January 2017

  3. Research article

    Brain metabolic pattern analysis using a magnetic resonance spectra classification software in experimental stroke

    Magnetic resonance spectroscopy (MRS) provides non-invasive information about the metabolic pattern of the brain parenchyma in vivo. The SpectraClassifier software performs MRS pattern-recognition by determin...

    Elena Jiménez-Xarrié, Myriam Davila, Ana Paula Candiota, Raquel Delgado-Mederos, Sandra Ortega-Martorell, Margarida Julià-Sapé, Carles Arús and Joan Martí-Fàbregas

    BMC Neuroscience 2017 18:13

    Published on: 13 January 2017

  4. Research Article

    CX3C chemokine receptor 1 deficiency modulates microglia morphology but does not affect lesion size and short-term deficits after experimental stroke

    The fractalkine/CX3C chemokine receptor 1 (CX3CR1) pathway has been identified to play an essential role in the chemotaxis of microglia, leukocyte trafficking and microglia/macrophage recruitment. It has also bee...

    Gerlinde van der Maten, Vivien Henck, Tadeusz Wieloch and Karsten Ruscher

    BMC Neuroscience 2017 18:11

    Published on: 6 January 2017

  5. Research Article

    Investigating potentially salvageable penumbra tissue in an in vivo model of transient ischemic stroke using sodium, diffusion, and perfusion magnetic resonance imaging

    Diffusion magnetic resonance imaging (MRI) is the current-state-of-the-art technique to clinically investigate acute (0–24 h) ischemic stroke tissue. However, reduced apparent diffusion coefficient (ADC)—cons...

    Friedrich Wetterling, Eva Chatzikonstantinou, Laurent Tritschler, Stephen Meairs, Marc Fatar, Lothar R. Schad and Saema Ansar

    BMC Neuroscience 2016 17:82

    Published on: 7 December 2016

  6. Research Article

    CatWalk gait analysis in a rat model of multiple sclerosis

    Myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) is a widely used animal model for multiple sclerosis. The characteristic feature of the MOG-EAE model in Brown...

    Sabine Herold, Prateek Kumar, Klaus Jung, Irina Graf, Henrike Menkhoff, Xenia Schulz, Mathias Bähr and Katharina Hein

    BMC Neuroscience 2016 17:78

    Published on: 30 November 2016

  7. Research Article

    Leucine-rich repeat kinase 2 (LRRK2) regulates α-synuclein clearance in microglia

    α-Synuclein (αSYN) has been genetically implicated in familial and sporadic Parkinson’s disease (PD), and is associated with disease susceptibility, progression and pathology. Excess amounts of αSYN are toxic ...

    Tatsunori Maekawa, Toshikuni Sasaoka, Sadahiro Azuma, Takafumi Ichikawa, Heather L. Melrose, Matthew J. Farrer and Fumiya Obata

    BMC Neuroscience 2016 17:77

    Published on: 30 November 2016

  8. Research article

    Interleukin-1 receptor (IL-1R) mediates epilepsy-induced sleep disruption

    Sleep disruptions are common in epilepsy patients. Our previous study demonstrates that homeostatic factors and circadian rhythm may mediate epilepsy-induced sleep disturbances when epilepsy occurs at differen...

    Tzu-Rung Huang, Shuo-Bin Jou, Yu-Ju Chou, Pei-Lu Yi, Chun-Jen Chen and Fang-Chia Chang

    BMC Neuroscience 2016 17:74

    Published on: 22 November 2016

  9. Review

    mTOR and MAPK: from localized translation control to epilepsy

    Epilepsy is one of the most common neurological diseases characterized by excessive hyperexcitability of neurons. Molecular mechanisms of epilepsy are diverse and not really understood. All in common is the mi...

    Helena F. Pernice, Rico Schieweck, Michael A. Kiebler and Bastian Popper

    BMC Neuroscience 2016 17:73

    Published on: 17 November 2016

  10. Methodology article

    A method for isolation of cone photoreceptors from adult zebrafish retinae

    Cone photoreceptors are specialised sensory retinal neurons responsible for photopic vision, colour perception and visual acuity. Retinal degenerative diseases are a heterogeneous group of eye diseases in whic...

    Antonino Glaviano, Andrew J. Smith, Alfonso Blanco, Sarah McLoughlin, Maria L. Cederlund, Theresa Heffernan, Beata Sapetto-Rebow, Yolanda Alvarez, Jun Yin and Breandán N. Kennedy

    BMC Neuroscience 2016 17:71

    Published on: 7 November 2016

  11. Research article

    Severe respiratory changes at end stage in a FUS-induced disease state in adult rats

    Fused in sarcoma (FUS) is an RNA-binding protein associated with the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration. ALS manifests in patients as a progres...

    Kasey L. Jackson, Hemangini A. Dhaibar, Robert D. Dayton, Sergio G. Cananzi, William G. Mayhan, Edward Glasscock and Ronald L. Klein

    BMC Neuroscience 2016 17:69

    Published on: 28 October 2016

  12. Research article

    Cortical processes of speech illusions in the general population

    There is evidence that experimentally elicited auditory illusions in the general population index risk for psychotic symptoms. As little is known about underlying cortical mechanisms of auditory illusions, an ...

    E. Schepers, L. Bodar, J. van Os and R. Lousberg

    BMC Neuroscience 2016 17:65

    Published on: 18 October 2016

  13. Research article

    Increased pro-inflammatory cytokines, glial activation and oxidative stress in the hippocampus after short-term bilateral adrenalectomy

    Bilateral adrenalectomy has been shown to damage the hippocampal neurons. Although the effects of long-term adrenalectomy have been studied extensively there are few publications on the effects of short-term a...

    Naserddine Hamadi, Azimullah Sheikh, Nather Madjid, Loai Lubbad, Naheed Amir, Safa Al-Deen Saudi Shehab, Fatima Khelifi-Touhami and Abdu Adem

    BMC Neuroscience 2016 17:61

    Published on: 1 September 2016

  14. Research article

    MicroRNA-34b mediates hippocampal astrocyte apoptosis in a rat model of recurrent seizures

    Recurrent convulsions can cause irreversible astrocyte death, impede neuron regeneration, and further aggravate brain damage. MicroRNAs have been revealed as players in the progression of numerous diseases inc...

    Liqun Liu, Lingjuan Liu, Jiayun Shi, Menglin Tan, Jie Xiong, Xingfang Li, Qingpeng Hu, Zhuwen Yi and Ding’an Mao

    BMC Neuroscience 2016 17:56

    Published on: 11 August 2016

  15. Research article

    TNFAIP1 contributes to the neurotoxicity induced by Aβ25–35 in Neuro2a cells

    Amyloid-beta (Aβ) accumulation is a hallmark of Alzheimer’s disease (AD) that can lead to neuronal dysfunction and apoptosis. Tumor necrosis factor, alpha-induced protein 1 (TNFAIP1) is an apoptotic protein th...

    Ning Liu, Zhanyang Yu, Yu Xun, Miaomiao Li, Xiaoning Peng, Ye Xiao, Xiang Hu, Yi Sun, Manjun Yang, Shiquan Gan, Shishan Yuan, Xiaoying Wang, Shuanglin Xiang and Jian Zhang

    BMC Neuroscience 2016 17:51

    Published on: 18 July 2016

  16. Research article

    Paclitaxel causes degeneration of both central and peripheral axon branches of dorsal root ganglia in mice

    Peripheral neuropathy is a common and dose-limiting side effect of many cancer chemotherapies. The taxane agents, including paclitaxel (Taxol®), are effective chemotherapeutic drugs but cause degeneration of pred...

    Aniqa Tasnim, Zoe Rammelkamp, Amy B. Slusher, Krystyna Wozniak, Barbara S. Slusher and Mohamed H. Farah

    BMC Neuroscience 2016 17:47

    Published on: 11 July 2016

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