Cellular and molecular mechanisms

Section edited by Maurizio Popoli, Vijiyalaxmi Ravindraneth and Mark Rasenick

This section covers all aspects of cellular and molecular neuroscience. Topics of interest are widespread and include, but are not limited to, neurotransmitters, neuropsychopharmacology, cell signaling, neurophysiology and glial development.

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  1. Research article

    Effects of escitalopram and paroxetine on mTORC1 signaling in the rat hippocampus under chronic restraint stress

    Recent studies have suggested that the activation of mammalian target of rapamycin (mTOR) signaling may be related to antidepressant action. Therefore, the present study evaluated whether antidepressant drugs ...

    Mi Kyoung Seo, Cheol Min Choi, Roger S. McIntyre, Hye Yeon Cho, Chan Hong Lee, Rodrigo B. Mansur, Yena Lee, Jae-Hon Lee, Young Hoon Kim, Sung Woo Park and Jung Goo Lee

    BMC Neuroscience 2017 18:39

    Published on: 26 April 2017

  2. Research article

    Transcriptional signatures of steroid hormones in the striatal neurons and astrocytes

    The mechanisms of steroids actions in the brain mainly involve the binding and nuclear translocation of specific cytoplasmic receptors. These receptors can act as transcription factors and regulate gene expres...

    Marcin Piechota, Michał Korostynski, Slawomir Golda, Joanna Ficek, Danuta Jantas, Ziolkowska Barbara and Ryszard Przewlocki

    BMC Neuroscience 2017 18:37

    Published on: 5 April 2017

  3. Research article

    Selenium suppresses glutamate-induced cell death and prevents mitochondrial morphological dynamic alterations in hippocampal HT22 neuronal cells

    Previous studies have indicated that selenium supplementation may be beneficial in neuroprotection against glutamate-induced cell damage, in which mitochondrial dysfunction is considered a major pathogenic fea...

    Yan-Mei Ma, Gordon Ibeanu, Li-Yao Wang, Jian-Zhong Zhang, Yue Chang, Jian-Da Dong, P. Andy Li and Li Jing

    BMC Neuroscience 2017 18:15

    Published on: 19 January 2017

  4. Research Article

    Poly(ADP-ribose) polymerase inhibitors activate the p53 signaling pathway in neural stem/progenitor cells

    Poly(ADP-ribose) polymerase 1 (PARP-1), which catalyzes poly(ADP-ribosyl)ation of proteins by using NAD+ as a substrate, plays a key role in several nuclear events, including DNA repair, replication, and transcri...

    Akiko Okuda, Suguru Kurokawa, Masanori Takehashi, Aika Maeda, Katsuya Fukuda, Yukari Kubo, Hyuma Nogusa, Tomoka Takatani-Nakase, Shujiro Okuda, Kunihiro Ueda and Seigo Tanaka

    BMC Neuroscience 2017 18:14

    Published on: 17 January 2017

  5. Research article

    Genistein protects against Aβ25–35 induced apoptosis of PC12 cells through JNK signaling and modulation of Bcl-2 family messengers

    Deposition of aggregated amyloid beta (Aβ) protein is hallmark of Alzheimer’s disease, leading to dysfunction and apoptosis of neurons. The isoflavone phytoestrogen compound genistein (Gen) exerts a significan...

    Fuling You, Qiao Li, Guifang Jin, Yaojie Zheng, Jingrong Chen and Hong Yang

    BMC Neuroscience 2017 18:12

    Published on: 12 January 2017

  6. Research article

    TfAP-2 is required for night sleep in Drosophila

    The AP-2 transcription factor APTF-1 is crucially required for developmentally controlled sleep behavior in Caenorhabditis elegans larvae. Its human ortholog, TFAP-2beta, causes Char disease and has also been lin...

    Mariya M. Kucherenko, Vinodh Ilangovan, Bettina Herzig, Halyna R. Shcherbata and Henrik Bringmann

    BMC Neuroscience 2016 17:72

    Published on: 9 November 2016

  7. Research article

    Neuroprotective effects of HTR1A antagonist WAY-100635 on scopolamine-induced delirium in rats and underlying molecular mechanisms

    Limited surveys have assessed the performance of 5-hydroxytreptamine receptor 1A and its antagonist WAY-100635 in pharmacological manipulations targeting delirium therapies. The purpose of this paper was to as...

    Yimin Qiu, Dongmei Chen, Xiaojing Huang, Lina Huang, Liang Tang, Jihong Jiang, Lianhua Chen and Shitong Li

    BMC Neuroscience 2016 17:66

    Published on: 19 October 2016

  8. Research article

    Decreasing the expression of PICALM reduces endocytosis and the activity of β-secretase: implications for Alzheimer’s disease

    Polymorphisms in the gene for phosphatidylinositol binding clathrin assembly protein (PICALM), an endocytic-related protein, are associated with a small, increased risk of developing Alzheimer’s disease (AD), ...

    Rhian S. Thomas, Alex Henson, Amy Gerrish, Lesley Jones, Julie Williams and Emma J. Kidd

    BMC Neuroscience 2016 17:50

    Published on: 18 July 2016

  9. Research article

    Histological characterization of orphan transporter MCT14 (SLC16A14) shows abundant expression in mouse CNS and kidney

    MCT14 (SLC16A14) is an orphan member of the monocarboxylate transporter (MCT) family, also known as the SLC16 family of secondary active transmembrane transporters. Available expression data for this transport...

    Sahar Roshanbin, Frida A. Lindberg, Emilia Lekholm, Mikaela M. Eriksson, Emelie Perland, Johan Åhlund, Amanda Raine and Robert Fredriksson

    BMC Neuroscience 2016 17:43

    Published on: 1 July 2016

  10. Methodology article

    A non-aggressive, highly efficient, enzymatic method for dissociation of human brain-tumors and brain-tissues to viable single-cells

    Conducting research on the molecular biology, immunology, and physiology of brain tumors (BTs) and primary brain tissues requires the use of viably dissociated single cells. Inadequate methods for tissue diss...

    Ilan Volovitz, Netanel Shapira, Haim Ezer, Aviv Gafni, Merav Lustgarten, Tal Alter, Idan Ben-Horin, Ori Barzilai, Tal Shahar, Andrew Kanner, Itzhak Fried, Igor Veshchev, Rachel Grossman and Zvi Ram

    BMC Neuroscience 2016 17:30

    Published on: 1 June 2016

  11. Methodology article

    A new in vitro mouse oligodendrocyte precursor cell migration assay reveals a role for integrin-linked kinase in cell motility

    The decline of remyelination in chronic multiple sclerosis (MS) is in part attributed to inadequate oligodendrocyte precursor cell (OPC) migration, a process governed by the extracellular matrix (ECM). Elucida...

    Ryan W. O’Meara, Sarah E. Cummings, John-Paul Michalski and Rashmi Kothary

    BMC Neuroscience 2016 17:7

    Published on: 1 February 2016

  12. Research article

    Gamma oscillation in functional brain networks is involved in the spontaneous remission of depressive behavior induced by chronic restraint stress in mice

    Depression is one of the most prevalent mood disorders, and is known to be associated with abnormal functional connectivity in neural networks of the brain. Interestingly, a significant proportion of patients ...

    Arshi Khalid, Byung Sun Kim, Bo Am Seo, Soon-Tae Lee, Keun-Hwa Jung, Kon Chu, Sang Kun Lee and Daejong Jeon

    BMC Neuroscience 2016 17:4

    Published on: 12 January 2016

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