Volume 9 Supplement 1

Seventeenth Annual Computational Neuroscience Meeting: CNS*2008

Open Access

The cerebellum connectivity in mathematics cognition

BMC Neuroscience20089(Suppl 1):P155

DOI: 10.1186/1471-2202-9-S1-P155

Published: 11 July 2008


It has been reported that cerebellum plays an important role in cognition [13], but the material function of cerebellum in cognition is still in debate. Previous studies have mainly focused on cerebellum activation during different cognitive processing and few studies have addressed the function of cerebellum in math cognition using connectivity analyses between the cerebellum and cerebral cortex. The within-condition interregional covariance analysis (WICA) is a novel method for ROI-based functional connectivity analyses which has been applied in language and math processing [4, 5]. In this study, we applied WICA to research the functional connectivity between cerebellum and cerebrum using the single digit addition and comparison tasks of math cognition. Fifteen native Chinese undergraduates participated in the experiment and a 1.5 T MRI scanner (GE_SIGNA, Milwaukee, WI) was recruited for brain imaging. We found that the activation of the cerebellum in math cognition had a tendency for left laterality and was modulated by the task difference and difficulty. Moreover, the cerebellum had strong connections with several brain regions in the frontal lobe using WICA, and the connections were also task sensitive.


Our results indicate that the cerebellum plays an important role in single digit addition and comparison tasks of math cognition, but the function of cerebellum in math cognition cooperates with the frontal lobe to perform the simple math task.



This work was supported in part by National Natural Science Foundation of China Grant 60472017 and 30670699, Ministry of Education Grant NCET-06-0277 and 021010.

Authors’ Affiliations

Institute of Neuroinformatics and Laboratory for Brain and Mind, Dalian University of Technology
Department of Psychology, University of Oregon


  1. Allen G, McColl R, Barnard H, et al: Magnetic resonance imaging of cerebellar-prefrontal and cerebellar-parietal functional connectivity. Neuroimage. 2005, 28 (1): 39-48. 10.1016/j.neuroimage.2005.06.013.View ArticlePubMedGoogle Scholar
  2. Guenther FH, Ghosh SS, Tourville JA: Neural modeling and imaging of the cortical interactions underlying syllable production. Brain and Language. 2005, 96 (3): 280-301. 10.1016/j.bandl.2005.06.001.PubMed CentralView ArticlePubMedGoogle Scholar
  3. Schmahmann JD, Caplan D: Cognition, emotion and the cerebellum. Brain. 2006, 129 (Pt 2): 288-292.Google Scholar
  4. He AG, Tan LH, Tang YY, et al: Modulation of neural connectivity during tongue movement and chinese "pin-yin" speech. Human Brain Mapping. 2003, 18 (3): 222-232. 10.1002/hbm.10097.View ArticlePubMedGoogle Scholar
  5. Tang YY, Zhang WT, Chen KW, et al: Arithmetic processing in the brain shaped by cultures. Proc Natl Acad Sci USA. 2006, 103 (28): 10775-10780. 10.1073/pnas.0604416103.PubMed CentralView ArticlePubMedGoogle Scholar


© Feng et al; licensee BioMed Central Ltd. 2008

This article is published under license to BioMed Central Ltd.