Volume 8 Supplement 2

Sixteenth Annual Computational Neuroscience Meeting: CNS*2007

Open Access

The study of nonlocal neural populations involving two neuron types and the effect of propofol

BMC Neuroscience20078(Suppl 2):S11

DOI: 10.1186/1471-2202-8-S2-S11

Published: 6 July 2007

The work derives a neural population model, which considers excitatory and inhibitory synapses as well as excitatory and inhibitory neurons. Then the spatio-temporal dynamics of the neural population is studied subject to the increase of the inhibitory synaptic decay rate. This study is motivated by the effect of the anaesthetic propofol, which increases the inhibitory synaptic decay rate with increased blood concentration and may yield loss of consciousness. We find regimes of stationary multistability and stability criteria for the stationary states. It turns out that the increase and subsequent decrease of propofol yields saddle-node bifurcations in a hysteresis loop.

Authors’ Affiliations

Department of Physics, University of Ottawa
Institute of Physics, Humboldt University


© Hutt et al; licensee BioMed Central Ltd. 2007

This article is published under license to BioMed Central Ltd.