Volume 8 Supplement 2

Sixteenth Annual Computational Neuroscience Meeting: CNS*2007

Open Access

A computational approach to dendritic spine motility with calcium signaling by the immersed boundary method with advection-electrodiffusion

BMC Neuroscience20078(Suppl 2):P95

DOI: 10.1186/1471-2202-8-S2-P95

Published: 6 July 2007

Dendritic spines are small protrusions from the dendritic branches of neurons. Influenced by internal and external signals and forces, even adult spines are not static but dynamically move. In this paper, we consider actomyosin-based spine motility with calcium signaling. The simulation begins with influx of calcium ions through glutamate receptors. Calcium Induced Calcium Release (CICR) with IP3 (inositol-1,4,5-trisphosphate) dynamics is also considered. The sensitivity of elasticity of actomyosin network is assumed to follow a Hill-type function of Ca2+ concentration. Several combinations in size of spine head and neck, physiology of Endoplasmic Reticulum (ER), and distribution of receptor/channels/exchangers are considered. Different functions of a spine as absorber, pumper and/or diffuser are observed. The computational framework used for these studies is the immersed boundary method with advection-electrodiffusion.

Authors’ Affiliations

Courant Institute of Mathematical Sciences, New York University


© Lee and Peskin; licensee BioMed Central Ltd. 2007

This article is published under license to BioMed Central Ltd.