Volume 8 Supplement 1

Annual Meeting of the Study Group Neurochemistry. International Conference of the Gesellschaft für Biochemie und Molekularbiologie 2006 (GBM 2006): Molecular pathways in health and disease of the nervous system

Open Access

Pannexin1 is a novel protein component of postsynaptic sites

  • Georg Zoidl1,
  • Elisabeth Petrasch-Parwez1,
  • Arundhati Ray1,
  • Carola Meier1,
  • Stephanie Bunse1,
  • Hans-Werner Habbes1,
  • Gerhard Dahl1 and
  • Rolf Dermietzel1
BMC Neuroscience20078(Suppl 1):P8

DOI: 10.1186/1471-2202-8-S1-P8

Published: 23 March 2007

Pannexins (Panx) constitute a new family of gap junction type proteins. Functional expression in paired Xenopus oocytes indicated that pannexins are capable of forming communicating junctions and proved to be active in forming of unapposed hemichannels. In the vertebrate brain pannexins have been found in neurons. However, the exact localization of pannexin proteins at the submicroscopical level in brain tissues is still enigmatic.

Here we demonstrate by light and electron microscopical immunohistochemistry that Panx1 reveals postsynaptic localization in hippocampal and cortical principal neurons accumulating at postsynaptic densities. Heterologeous expression in hippocampal neurons co-transfected with Panx1 and PSD-95, a prominent postsynaptic scaffolding protein, corroborated the postsynaptic localization. The asymmetric distribution of Panx1 suggests that it may work in form of hemichannels at postsynaptic sites and comprises a novel component of the postsynaptic protein complex.

Authors’ Affiliations

(1)
Dept. Neuroanatomy and Molecular Brain Research

Copyright

© Zoidl et al; licensee BioMed Central Ltd. 2007

This article is published under license to BioMed Central Ltd.

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